Shi, "Glycation of human serum albu- min in diabetes: Impacts on the structure and function," Current Medicinal Chemistry, vol. 22, no. 1, pp. 4-13, 2015.Cao H, Chen T, Shi Y (2015) Glycation of human serum albumin in diabetes: impacts on the structure and function. Curr Med ...
Liraglutide's protracted action highly depends on its capacity to bind to albumin via its palmitic acid part. However, in diabetes, albumin can undergo glycation, resulting in impaired drug binding. Our objective in this study was to assess the impact of human serum albumin (HSA) glycation on ...
Modification of proteins by nonenzymatic glycation is one of the underlying factors that contribute to the development of the complications of diabetes. Human serum albumin (HSA) is one of the major targets of interaction with glucose through the Maillard reaction. The effects of 1 and 5 mg/ml ...
Therefore, the effects of glycated human serum albumin on human umbilical vein endothelial cells were studied.MethodsReactive oxygen species production was measured by the cytochrome C reduction method and by 5(6)-carboxy-2,7-dichlorofluorescein diacetate (c-DCF-DA) fluorescence after treating human ...
Glycation of proteins has been thought to evoke an oxidative stress state in vivo, but the detailed process involved is unclear. We estimated the reactivity of All during the glycation of human serum albumin (HSA), which was carried out in the presence of All, D-glucose (Glc), D-fructose...
Glycation (or non-enzymatic glycosylation) is a common non-enzymatic covalent modification of human proteins. Glucose, the highest concentrated monosaccharide in blood, can reversibly react with amino groups of proteins to form Schiff bases that can rearrange to form relatively stable Amadori products....
Glycation up to 3 molglc/mol protein of human serum albumin, in contrast to previous reports, did not affect the binding of up to 2 mol palmitate, which was reached at a ratio of 7.5 palmitate/HSA. The uptake of palmitate from albumin by either erythrocytes or HL-60 cells also was not...
In the last phase, advanced glycation end products (AGE) are irreversibly formed following a complex cascade of reactions. It has recently been shown that glycation also affects diabetes-related complications and Alzheimer's disease. In this study, human serum albumin at a concentration of 10 mg/...
Diabetes mellitus is one of the most serious diseases in the world. The degree of glycated plasma proteins is increased in diabetics compared to non-diabetic subjects. This mini-review focuses on the influence of glycation of human serum albumin (HSA) in diabetes on the binding interaction with...
Background— Non-enzymatic glycation of human serum albumin (HSA) is associated with the long-term complications of diabetes. We examined the structure and location of modifications on minimally glycated HSA and considered their possible impact on the binding of drugs to this protein. Methods— Mini...