(a) Schematic view of H-bonded GSH-ligand domains on the surface of citrate-capped AuNPs and (b) SPR absorption band shifting due to necklace-like agglomeration of AuNPs. An optical measurement beam, that is, the light beam in a spectrophotometer or the laser pump beam in AOPAS, detects ...
(ida2−) coupled through the nitrogen to the support phase. When the binding ligand portion is loaded by labilemetal ionssuch as CuII, NiII, ZnII, the supported-M(ida) or similarmetal complexis termed an IMACbinding site. The IMAC site can still bind to side-chain groups from a ...
, β (β1a and β1b), γ (γ1a and γ1b), λ, ω, ε, κ, etc.), intracellular adhesion molecule, keratinocyte growth factor (KGF), P-selectin glycoprotein ligand (PSGL), transforming growth factor, lactase, leptin, leuprolide, luteinizing hormone, natriuretic peptide (ANP, BNP, or ...
Among these modifications, O-acetylation plays a crucial role in the regulation of ligand function of terminal sialic acids on N-glycans63. It is well established that the attachment of influenza A and B viruses can be inhibited by O-acetylation of sialylated ligands owing to reducing viral ...
The rat is an important alternative for studying human pathology owing to certain similarities to humans. Glycomic studies on rat serum have revealed that variations in the N-glycans of glycoproteins correlated with disease progression, which is consiste
An exception isthe different chelation pattern determined for PhePhe versus HisGly,reflecting the intercalation-type cation binding pocket of the PhePheligand. The complexes group into three well-defined spectroscopicpatterns: nickel and magnesium, calcium and barium, and potassium.Factors leading to ...
For this reason, constraint of side-chain moieties is used to determine the 3D pharmacophore necessary to understand the 3D requirements of a ligand’s bio-activity [19] (for χ-constraint see later). Bryan et al. [20] designed δ-selective cyclic enkephalins, associating the disulfide bridge...
Ligand substitution Reaction (31)121 proceeds in Me2SO. It is an extension of Reaction (20) in which R′SH = Ac-Cys-NHMe or a glycyl–cysteinyl oligopeptide such as 12-(Cys)4peptide = tBoc–Gly–Cys–(Gly)2–Cys–(Gly)2–Cys–(Gly)2–Cys–Gly–NH2. The peptide carries the Cys...
The binding energy is greater for transition metal ion-bound species than the alkaline earth metal ion-bound ones due to ligand–field stabilization, and Cu2+ adopts a weakly negative charge upon complexation, leading to unique dissociation behavior of [Cu·PheGlyGly-H]+. Observation of sequence...
The values of kobs obtained were fitted to a single ligand binding site with a defined background using the following equation to obtain Kd(app),(Eq. 4)kobs=k4+(k3·APPI)/(Ki(app)+APPI) where the y intercept yields k4, the plateau value of kobs yields (k3 + k4), and the mid...