it is only recently that a connection betweeninsulin signalingpathway andglucose uptakeby GLUT4 has been established (Sano et al., 2003). Sano et al. identified an Akt substrate of 160kDa (AS160) as the link between the PI3K-insulinsignaling pathwayand membrane trafficking. This protein has ...
The glucose metabolism of trophoblasts is possibly regulated through the IRS1/GLUT4 signaling pathway in mice fed with a high-fat diet after FGF(fibroblast growth factor) is given21. Currently, glucose uptake and transport in the placenta are primarily mediated by GLUT1 and GLUT322. GLUT1 is...
S. (2014) A proteolytic pathway that controls glucose uptake in fat and muscle. Rev Endocr Metab Disord 15, 55-66.Belman, J. P., Habtemichael, E. N., and Bogan, J. S. (2014) A proteolytic pathway that controls glucose uptake in fat and muscle. Reviews in endocrine & metabolic ...
To identify the pathway through which miR-21 promotes glucose uptake, we examined the mRNA expression of five important Gluts in WT and miR-21βKO islets stimulated with glucose in vitro. The results showed that Glut2 has the highest expression level in the islets and its expression was ...
role of mouse olfactory receptor 23 (MOR23) in regulation of glucose uptake in myotubes and adipocytes and investigate whether administration of a possible MOR23 ligand, α-cedrene, attenuates the high-fat diet (HFD)-induced glucose intolerance by enhancing the OR-mediated signaling pathway in ...
Major facilitative glucose transporters of the GLUT family in the liver, skeletal muscle, and adipose tissue. Several glucose transporters of the SLC4A2 family are involved in cellular uptake of hexoses. Entry of glucose into hepatocytes is mainly catalyzed by the low-affinity, high-capacity GLUT2...
Finally, 2DOG uptake was significantly enhanced in cells cultured under high-glucose (22.2 mm) conditions as compared with that in cells under normal glucose (5.6 mm) conditions, and this increase in 2DOG uptake in cells under high-glucose conditions was inhibited by the addition of anti–TGF...
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centrations of 0.5 and 1 μM also significantly inhibited insulin-stimulated glucose uptake in a dose-dependent manner (P<0.05;Figure 5B).These observations in-dicate that the PI3-K pathway may be involved in the insulin-stimulated glucose uptake in BMEC. DISCUSSION Figure 2.Glucose uptake of...
Human SWEET1 does not cause the uptake of glucose, but mediates a weak efflux. It was found predominantly in the Golgi apparatus with a minimum expression in the plasma membrane. Human SWEET1 shows the highest level of expression in the oviduct, epididymis, and intestines; to date, no ...