GLP-1R agonist group and diabetes-model group were administered with GLP-1R agonist in dose 5 μg/kg each time, twice a day. After 10 weeks of treatment, the amount of matrix metalloproteinase (MMP)-2 and MMP-9, and expression of α-smooth muscle actin (α-SMA) and type \\{III\...
Hence, we hypothesize that GLP-1R signaling in cardiac blood vessels, perhaps in endothelial cells or smooth muscle cells, may also contribute in part to modulation of blood flow and cardioprotection. Indeed, Richards et al. used expression of a fluorescent reporter protein under control of endogen...