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Innovator drugs targeting GLP1R witnessed a 595% increase in total licensing agreement deal value from 2019 to 2024 YTD.
The aims of this study were to investigate a GCGR-biased co-agonist as treatment for hepatic steatosis in mice. METHODS: Mice with diet-induced obesity (DIO) were treated with Dicretin, a GLP1/GCGR co-agonist with high potency at the GCGR, Semaglutide (GLP1R monoagonist) or food ...
is a short-acting GLP-1R agonist that is injected once daily for the treatment of type 2 diabetes.Although several GLP-1R agonists are currently available on the market, researchers are exploring more effective agents, including oral forms of GLP-1R agonists, drugs with longer duration of action...
Strategies that elevate cardiac cAMP levels, such as PDE4 inhibition, may potentiate the cardiovascular, including anti-inflammatory, benefits of GLP1R agonist drugs. 显示全部 2024-10-01·METABOLISM-CLINICAL AND EXPERIMENTAL Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP...
The glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide has revolutionized the treatment of obesity, with other gut hormone-based drugs lined up that show even greater weight-lowering ability in obese patients. Nevertheless, bariatric surgery remains the mainstay treatment for severe obesity...
However, the currently marketed peptidyl GLP-1R agonist drugs are restricted by the requirement of injection. Hence, there is a continued need to develop orally bioavailable small molecule GLP-1R agonist drugs that could be beneficial for the treatment of T2DM. In this study, we report a new ...
Key words: GLP-1R ;molecular structure ;small molecule drugs 胰高血糖素样肽 -1 受体(glucagon-like peptide-1 receptor,GLP-1R)是 2- 型糖尿病最为有效的治疗 靶点之一.经过多年基础研究积累,转化和临床研 究表明 GLP-1 与其受体相互作用能够有效调控机体 糖稳态和能量代谢[1].GLP-1R 属于 G 蛋白偶联...