[2] Ma, X. et al. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells". Journal of Diabetes. 2014, 6, 394–402. [3] Gautier, J. F. et al. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & Metabolism....
SUSTAIN4阶段:两个规格(0.5mg与1.0mg)的索玛鲁肽与甘精胰岛素(Insulin Glargine,商品名:Lantus来得时)相比,在治疗第30周,甘精胰岛素治疗组的HbA1c降低了0.9%,而索玛鲁肽(0.5mg)和索玛鲁肽(1.0mg)治疗组的HbA1c分别降低了1.2%和1.5%,具有显著的统计学差异(P值均<0.0001),对2型糖尿病成年患者的血糖有明显改...
1.Deborah Hinnen, Glucagon-Like Peptide 1 Receptor Agonists for Type 2 Diabetes, Diabetes Spectr. 2017 Aug;30(3):202-210. 2.Joseph Nowell, Eleanor Blunt and Paul Edison, Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease, Molecular Psychiatry (...
参考文献 Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. Regul Pept. 2007 Oct 4;143(1-3):64-8.
8. Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015;125(12):4714–4728. doi: 10.1172/JCI81975. ...
近几年,随着GLP-1R激动剂类药物市场规模不断增长,美国降糖药物市场发生了趋势转变,由之前insulin(胰岛素)类药物的霸主地位演变为GLP-1类药物领衔,据药融云医药数据库-上市年报统计2022年诺和诺德和礼来GLP-1业务收入总计超195亿美元,平均同比增长35%以上。
值得注意的是,此次风险并非针对诺和诺德的司美格鲁肽一个药品,而且GLP-1的一大类,包括Dulaglutide、Exenatide、Insulin Degludec+Liraglutide、Liraglutide、Lixisenatide、Insulin Glargine+Lixisenatide、Semaglutide。并要求诺和诺德、礼来、阿斯利康、赛诺菲四家公司在7月26日前补充风险信息。
[4] Calkin, Cynthia V et al. “Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression (the TRIO-BD Study): A Randomized, Quadruple-Masked, Placebo...
6.肠泌素: GLP1、GIP(原理直接促进Insulin/胰岛素分泌); 7.GLP类似物和GLP-1受体激动剂(原理直接促进Insulin/胰岛素分泌); 8.二肽基肽酶-4(DPP-4)抑制剂(原理间接促进Insulin/胰岛素分泌); 9.噻唑烷二酮类(原理增加身体细胞对葡萄糖的需求); 10.钠-葡萄糖协同转运...
[22] Chang, C.C., Lin, T.C., Ho, H.L., Kuo, C.Y., Li, H.H., Korolenko, T.A., et al. 2018. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Int J Mol Sci 19. ...