GLP1与DPP4课件.ppt,* GLP-1主要是针对胰岛的α和β双细胞发挥作用,从而抑制血糖升高。 对于β细胞,GLP-1能够改善β细胞的功能和β细胞的量,从而葡萄糖浓度依赖性的促进胰岛素的合成和分泌。 对于α细胞,GLP-1则通过直接和间接作用葡萄糖浓度依赖性的抑制胰高糖素分泌,
Combination thera- pies of DPP4 inhibitors and GLP1 analogues with insulin in type 2 diabetic patients: a systematic review. Curr Vasc Pharmacol 2012; June 22, [Epub ahead of print].Rizos EC, Ntzani EE, Papanas N, Tsimihodimos V, Mitrogianni Z, Maltezos E, et al. Combination therapies...
induced MI in wild type mice and in mice treated with the DPP-4i inhibitor sitagliptin or with genetic deletion of DPP-4 (dpp4−/−) after induction of diabetes with high-fat diet and streptozotocin. Dpp4−/− mice showed an increased survival after MI compared with dpp4+/+ mice ...
et al. DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat. Obesity (Silver Spring) 22, 2172–2179 (2014). Article CAS Google Scholar Kanasaki, K. et al. Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabet...
胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是胰高血糖素前驱体的一部分。胰高血糖素前驱体于胰脏、小肠下部以及下丘脑中表达。该前驱体的构造中含有与糖代谢有关的各种各样的生理活性物质(胰高血糖素,肠高血糖素,胃泌酸调节素,GLP-1,GLP-2)的氨基酸序列。根据表达部位加工酶的特异性,胰脏主要分泌胰...
DPP-4 is a part of the serine protease family that is found in two membrane-bound and soluble forms in various tissues such as the heart, lung, kidney and liver. DPP4 can cleave various peptides, leading to inactivation and/or generation of new bioactive peptides. For instance, it is ca...
DPP-4 is a part of the serine protease family that is found in two membrane-bound and soluble forms in various tissues such as the heart, lung, kidney and liver. DPP4 can cleave various peptides, leading to inactivation and/or generation of new bioactive peptides. For instance, it is ca...
胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是胰高血糖素前驱体的一部分。胰高血糖素前驱体于胰脏、小肠下部以及下丘脑中表达。该前驱体的构造中含有与糖代谢有关的各种各样的生理活性物质(胰高血糖素,肠高血糖素,胃泌酸调节素,GLP-1,GLP-2)的氨基酸序列。根据表达部位加工酶的特异性,胰脏主要分泌胰...
DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2012;303(5):F681–8. Article CAS Google Scholar Kodera R, Shikata K, Kataoka HU, Takatsuka T, Miyamoto S, Sasaki M, et al. Glucagon-like peptide-1 receptor agonist ameliorates ...
Hanlon and colleagues also found DPP4 inhibitor use correlated with slightly improved HbA1c lowering in older people for dual therapy (AR, –0.09% per 30-year increment in age), but not monotherapy (AR, –0.08%) nor triple therapy (AR, –0.01%). Regarding age- and sex-specific effects f...