Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.GARY ERIK ASPNES...
GLP-1 Receptor Agonists and Uses Thereof Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds,... GE Aspnes,SW Bagley,EL Conn,... 被引量: 0发表: 2021年 Conjugates of GLP-1 agonists...
Insulinotropic peptides and compounds are agonists of the GLP-1 receptor. The insulinotropic property of a compound may be determined by in vitro or in vivo assays known in the art. In one embodiment of the invention the GLP-1 has an Arg residue in position 34. In another embodiment the ...
GLP-1 COMPOSITIONS AND USES THEREOF The present invention relates to compositions comprising the GLP-1 peptide liraglutide and a thiol-containing excipient. O Nordfang,M Eva Horn,A Staby 被引量: 0发表: 2018年 GLP-1 Receptor Agonists And Related Active Pharmaceutical Ingredients For Treatment Of ...
The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes
GLP-1 Receptor Agonists and Uses ThereofProvided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.GARY ERIK ASPNES...
Glucagon-like peptide 1 receptor agonists and their use The present invention provides modified glucagon-like peptide 1 (GLP1) polypeptides, fusion proteins containing modified GLP1 polypeptides, and uses thereo... ヤンウェイ,ハルカオカモト,ジェスパーグロマーダ,... 被引量: 0发表: 2020年...
GLP-1 molecules of the present invention include polynucleotides that express agonists of GLP-1 (i.e., activators of the GLP-1 receptor molecule and its secondary messenger activity found on, inter alia, insulin-producing p-cells). GLP-1 mimetics that also are agonists of β-cells include,...
Novel protracted GLP-1 compounds and therapeutic uses thereof. LAU Jesper,HANSEN Thomas Kruse - WO 被引量: 147发表: 2006年 Stable, protracted glp-1/glucagon receptor co-agonists for medical use The invention relates to novel stable and protracted GLP-1/glucagon receptor co-agonists, to the use...
To provide methods for prevention and/or treatment of cardiometabolic and associated diseases.SOLUTION: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, represented by the general formula in the figure.SELECTED...