Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.Gary Erik Aspnes...
It has been shown that peptide analogs of native GLP-2 possess enhanced trophic activity at the small intestine as GLP-2 receptor agonists (see for example U.S. Pat. No. 5,990,077). Although very useful, a critical disadvantage of GLP-2 peptides and analogs, as stated above, is their...
PROBLEM TO BE SOLVED: To provide compounds and methods for targeting cells expressing GLP-1 receptor.;SOLUTION: A compound comprises a modified oligonucleo... BP Monia,TP Prakash,GA Kinberger,... 被引量: 0发表: 2022年 GLP-1 receptor agonists and uses thereof Provided herein are 6-carboxylic...
Glucagon-like peptide 1 receptor agonists and their use The present invention provides modified glucagon-like peptide 1 (GLP1) polypeptides, fusion proteins containing modified GLP1 polypeptides, and uses thereo... ヤンウェイ,ハルカオカモト,ジェスパーグロマーダ,... 被引量: 0发表: 2020年...
Abstract: The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes (type 1 and/or type 2) and diabetes-related diseases or disorders....
GLP-1 receptor agonists and uses thereofProvided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.Gary Erik Aspnes...
Insulinotropic peptides and compounds are agonists of the GLP-1 receptor. The insulinotropic property of a compound may be determined by in vitro or in vivo assays known in the art. In one embodiment of the invention the GLP-1 has an Arg residue in position 34. In another embodiment the ...
GLP-1 COMPOSITIONS AND USES THEREOF The present invention relates to compositions comprising the GLP-1 peptide liraglutide and a thiol-containing excipient. O Nordfang,M Eva Horn,A Staby 被引量: 0发表: 2018年 GLP-1 Receptor Agonists And Related Active Pharmaceutical Ingredients For Treatment Of ...
GLP-1R AGONISTS AND USES THEREOF Provided are compounds of Formula (I) and pharmaceutical compositions thereof, for use in, e.g. treating type 2 diabetes mellitus, pre-diabetes, obesity, n... W Zhong 被引量: 0发表: 2022年 GLP-1 Receptor Agonists and Uses Thereof Provided herein are 6-...
13.The composition of claim 12, wherein X2 is Gly, X3 is Glu, X10 is Nle, X16 is Leu and R2 is NH2or CONH2. 14.The compound of claim 12, wherein said GLP-2 analog or variant has an amino acid sequence according to any one of SEQ ID NO: 1 through SEQ ID NO: 8. ...