[20] Bendotti, Giulia, et al. "The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists." Pharmacological Research 182 (2022): 106320.[21] Nevola, Riccardo, et al. "GLP-1 receptor agonists in non-alcoholic fatty liver disease: current evidence and future perspectives." ...
Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet β cells, promotion of islet β cell proliferation and ...
Figure 2. The role of GLP1 or GLP1R agonists [6]3、GLP1R信号作用机制 如前所述，GLP1R主要通过与其配体GLP1及其类似物结合激活后发挥生物学功能，这里重点介绍GLP1R在胰腺中的信号作用机制。在胰腺中，目前认为GLP-1R主要通过Gαs /cAMP 通路发出信号，但有证据表明GLP-1R也与Gαq和其他G蛋白偶联。GLP-...
GLUCAGON-like peptide-1 agonistsGLUCAGON-like peptide-1 receptorTYPE 2 diabetesDOPAMINE receptorsNEURODEGENERATIONParkinson's disease (PD) is one of the most common neurodegenerative diseases. Recent data highlight similarities between neurodegenerative diseases, including PD and type 2 d...
[3]Wei, Y., Mojsov, S. 1996. Distribution of GLP-1 and PACAP receptors in human tissues. Acta Physiol Scand 157:355-357. [4]Ban, K., Noyan-Ashraf, M.H., Hoefer, J., Bolz, S.S., Drucker, D.J., Husain, M. 2008. Cardioprotective and vasodilatory actions of glucagon-like pe...
[12] Rebosio, C., Balbi, M., Passalacqua, M., Ricciarelli, R., Fedele, E. 2018. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus. Biofactors 44:148-157...
了解GLP-1影响体重的相关机制。 自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用...
尽管GLP-1R激动剂以其促胰岛素和降低体重的作用而闻名,但它也对啮齿动物的心血管系统产生一系列有益的作用,包括通过抑制心肌细胞凋亡来增加心肌细胞存活,改善内皮功能障碍[8,11],改善损伤和心力衰竭后的局部和总心输出量[12,15](图1)...
These medications are referred to as GLP-1 agonists, meaning that they act on the same receptors in the body as Glucagon-like peptide 1 (GLP-1) and mimics the action of this hormone. GLP-1 is a hormone released from cells in the small intestine and colon in response to food intake. ...
[12] Rebosio, C., Balbi, M., Passalacqua, M., Ricciarelli, R., Fedele, E. 2018. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus. Biofactors 44:148-157. ...