4.Juan P Frias, Stanley Hsia, Sarah Eyde, Rong Liu, Xiaosu Ma, Manige Konig, Christof Kazda, Kieren J Mather, Axel Haupt, Edward Pratt, Deborah Robins, Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study, ...
去甲肾上腺素可以通过作用于α-肾上腺素受体抑制GLP-1的分泌,而异丙肾上腺素刺激GLP-1分泌可被β-肾上腺素能受体拮抗剂普萘洛尔阻断[66]。所以,肠道GLP-1的分泌受胆碱能和β-肾上腺素能受体信号刺激而增加,但因α-肾上腺素能受体的激活而被抑制。GRP由肠神经系统GRP能神经元产生和释放[67]。在大鼠中,当脂肪直接...
主要适应症为糖尿病、减重以及非酒精性脂肪性肝炎等。另外GX-G6(石药集团),ecnoglutide(先为达生物),HR170331(恒瑞医药),TTP273(中美华东)等药物处于临床II期。 GLP-1的生物类似药物研发方面:利拉鲁肽中国专利已到期,中美华东(华东医药全资子公司),翰宇医药,通化东宝已提交上市申请,其中华东医药已提交肥胖适应症上...
[54] Gyulkhandanyan, A.V., Lee, S.C., Bikopoulos, G., Dai, F., Wheeler, M.B. 2006. The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel. J Biol Chem 281:9361-937...
Bead TypeGLP-1 [21] Assay SensitivityAs determined for Lot 1: 17.8 pg/mL Assay RangeAs determined for Lot 1: 9.76 - 40,000 pg/mL FormatSimplex Kit For Use With (Equipment)Luminex™ Instruments GeneGlucagon Gene AliasGLP1; GLP2; GRPP; GLP-1 ...
PCSK1:激素前转化酶1/3;PCSK2:激素前转化酶2;NTS:孤束核;GRPP:肠高血糖素相关肽;IP-1:中间肽-1;IP-2:中间肽-2;MPGF:主要胰高糖素原片段;GLP-1:胰高糖素样肽-1;GLP-2:胰高糖素样肽-2。 GCG基因在胰腺、小肠...
including managing A1C levels and aiding weight loss in individuals with Type 1 diabetes. They are also approved for obesity treatment with medications like semaglutide and high-dose liraglutide. When considering GLP-1 agonists, it's crucial to consult a healthcare provider, especially fo...
[20] McCarty, D., Coleman, M., Boland, C.L. 2017. Lixisenatide: A New Daily GLP-1 Agonist for Type 2 Diabetes Management. Ann Pharmacother 51:401-409. [21] Finan, B., Clemmensen, C., Muller, T.D. 2015. Emerging opportunities for the treatment of metabolic diseases: Glucagon-like...
自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用甚至已经在中国以外的其他一部分国...
Mounjaro (tirzepatide) 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg per 0.5 mL injection, is a prescription medicine for adults with type 2 diabetes used along with diet and exercise to improve blood sugar (glucose). It is not known if Mounjaro can be used in people who ...