Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabolism...
Australia. Under the guidance of the innovation strategy, the R&D pipeline of Bejing Peptide has been advanced efficiently and the results have been continuous, which reflects the outstanding ability of Bejing Peptide in the field of innovative research and development in the field of metabolic ...
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different pepti
The more recent glucagon-like peptide-1 receptor agonists (GLP-1RAs) are non-insulin injectable options for the management of type 2 diabetes. Effective at improving glycaemic control with a low intrinsic risk of hypoglycaemia and the potential for weight reduction, this agent class is an ...
Australia. Under the guidance of the innovation strategy, the R&D pipeline of Bejing Peptide has been advanced efficiently and the results have been continuous, which reflects the outstanding ability of Bejing Peptide in the field of innovative research and development in the field of metabolic ...
The recently developed receptor agonists for glucagon-like peptide-1 (GLP-1RAs), stimulate insulin secretion and reduce glycated hemoglobin levels without having side effects such as weight gain and hypoglycemia. In addition, GLP1-RAs demonstrate numerous cardiovascular protective effects in subjects ...
Glucagon-Like Peptide-1 (GLP-1) is a 30-amino acid peptide primarily produced by endocrine cells in the intestines. As an incretin, GLP-1 regulates food intake and glucose homeostasis via central (e.g., hypothalamus) and peripheral (e.g., pancreas) mechanisms. GLP-1 also acts as a ...
Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of the GLP-1 analogs exendin-4 and liraglutide o
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Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R u