Multiple glucagon-like peptide-1 (GLP-1) agonist medications, created for the treatment of type 2 diabetes mellitus, are now labeled for the treatment of obesity. By activating GLP-1 peptides, these medications affect body weight in many ways, including inhibiting glucagon and stimulating insulin...
[6] Brown, E. et al. Newer GLP-1 receptor agonists and obesity-diabetes. Peptides. 2018, 100, 61-67. [7] O’Neil, P. M. et al. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with ...
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多肽药物似乎给出了一个药物减肥的可行方案。GLP-1(Glucagon-like peptide 1,胰高血糖素样1多肽)肩负了肥胖症患者的希望,尽管它们的出身并不是这个目的,而是II型糖尿病药物,但这正验证了“英雄不问出处”的道理。 要评论GLP-1多肽药物作为减肥药的效果,我们得一步一步地梳理。
然而，随着司美格鲁肽等GLP-1类药物的持续热销，我们有必要进一步探索其与非常道不良事件的相关性。2022年10月5日，英属哥伦比亚大学的研究人员在《美国医学会杂志》（JAMA）发表类题为：Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss（GLP-1受体...
安进的AMG133是一款APC药物(ANTIBODY-PEPTIDE CONJUGATE ),每个月用药一次,作用于GLP-1R/GIPR,在安进披露的的1期临床研究中,受试者经最高剂量AMG 133治疗3个月后体重减少了14.5%[14]。 安进133 GLP-1 APC药物,每月给药一次 Fractyl Health公司走的是GLP1基因疗法路线[15],通过AAV病毒载体,一次性注入胰腺可让...
Citations Metrics Reprints & Permissions Read this article Abstract Glucagon-like peptide-1 receptor agonists (GLP-1s) are commonly prescribed for managing Type II diabetes (T2D). These medications target GLP-1 receptors in the pancreas, intestines, and brain, stimulating insulin release, which...
今日,知名学术期刊《科学》公布胰高血糖素样肽-1(GLP-1)激动剂获选为2023年度科学突破(Science’s 2023 Breakthrough of the Year),这标志着在对抗肥胖症及其相关并发症的长期斗争中的重要里程碑。这项科学成就不仅在肥胖症治疗领域产生了深远影响,而且其潜在应用正被广泛研究,包括在治疗药物成瘾和神经退行性疾病等...