Dankner R, et al "Glucagon-like peptide-1 receptor agonists and pancreatic cancer risk in patients with type 2 diabetes" JAMA Netw Open 2023。
[13] FRACTYL HEALTH DEMONSTRATED SIGNIFICANT IMPROVEMENT IN WEIGHT LOSS IN HEAD-TO-HEAD PRECLINICAL OBESITY STUDIES OF ITS REJUVA® GLP-1- BASED PANCREATIC GENE THERAPY CANDIDATE (GLP-1 PGTX) COMPARED TO CHRONIC SEMAGLUTIDE AT EASD’S ANNUAL MEETING. Retrieved October 4, 2023 from https://www...
Dankner R, et al "Glucagon-like peptide-1 receptor agonists and pancreatic cancer risk in patients with type 2 diabetes" JAMA Netw Open 2023。
Pancreatic ductal adenocarcinomaCancer associated fibroblastsDiabetesObesityCollagen depositionMetabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense ...
Monami M, Nreu B, Scatena A, et al. Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. Diabetes Obes Metab. 2017 Sep;19(9):12...
GLP-1属于胰高血糖素家族成员。 产品图片 Paraformaldehyde-fixed, paraffin embedded (human pancreatic cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C ...
Duct cellular pancreatic cancerIncretinsLiraglutidePancreatitisIn this issue of Diabetologia, Ellenbroek and colleagues present a study of the effects of the glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, on beta cell function and mass in normoglycaemic mice [1]. The mice were ...
研究背景: 胰腺癌(Pancreatic Cancer)是恶性程度较高的消化道肿瘤。2013年美国新发胰腺癌病例为45,220,死亡人数高达38,460。在中国已占癌症死亡人口的第6-7位。由于缺乏可靠的癌症诊断标记物,胰腺癌早期诊断困难,发现时多已经局部扩散并全身性转移,丧失最佳手术机会[1];目前常见的胰腺癌治疗化学药物,例如5-氟尿嘧啶...
GLP-1属于胰高血糖素家族成员。 产品图片 Paraformaldehyde-fixed, paraffin embedded (human pancreatic cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C ...
Keywords:GLP-1 receptor agonists, endocrine, cardiovascular, neurological, cancer 关键词:GLP-1受体激动剂,内分泌,心血管,神经,癌症 Introduction 引言 Glucagon like peptide-1 (GLP-1) is a 30 or 31 amino acid long peptide hormone mainly secreted by 3 tissues in the human body: enteroendocrine L ...