In conclusion, pancreatic cancer-derived exosomes (Exo-Mia) suppress the synthesis of GIP and GLP-1 from STC-1 cells in vitro by down-regulating the PCSK1/3. Moreover, it may be the pancreatic juice that transport cancer-derived exosomes to target cells (K and L cells) in the gut....
一项历史队列研究报告称，开始治疗几年后，GLP-1 受体激动剂使用者并没有出现胰腺癌安全信号。Rachel Dankner 发现，与基础胰岛素使用者相比，服用 GLP-1 受体激动剂的人在接下来的 5 至 7 年内患胰腺癌的风险没有显着差异（HR 0.50，95% CI 0.15-1.71）。他们在研究中指出，该模型针对年龄、性别、种族...
Ryder RE. The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefits. Diabet Med. 2013;30(10): 1148-1155.Ryder,R.E.J..The potential risks of pancreatitis and pancreatic cancer with...
Monami M, Nreu B, Scatena A, et al. Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. Diabetes Obes Metab. 2017 Sep;19(9):12...
Interestingly, diabetes is not only associated with a higher risk to develop pancreatic cancer, but also might represent one of the first signs of its onset [7, 8]. This renders the association between diabetes and pancreatic cancer bidirectional and difficult to discern. Indeed, retrospective ...
Potential concerns surrounding GLP-include pancreatitis, pancreatic cancer, colorectal cancer, suicide and other phycological effects, and thyroid cancer. Daniel J. Drucker, MD, from Mt. Sinai Hospital, said, for glucagon-like peptide-1 (GLP-1) medications, the brain is responsible for many of th...
Elashoff found an elevated risk of pancreatitis and pancreatic cancer (PC) associated with treatment with DPP-4 inhibitor sitagliptin or GLP-1RA Exenatide compared to other medications by assessing the reported adverse events in the Food and Drug Administration (FDA) database. Patients treated with ...
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Glucose-Stimulated Insulin Secretion (GSIS) in Rat Pancreatic Islets The effects of 22 on GSIS were evaluated using rat pancreatic islets (Figure 5). At 10 mM glucose, both 22 and nEx4 increased GSIS in a dose-responsive manner. The effect from 22 was observed to be one-third lower than...