一项历史队列研究报告称，开始治疗几年后，GLP-1 受体激动剂使用者并没有出现胰腺癌安全信号。Rachel Dankner 发现，与基础胰岛素使用者相比，服用 GLP-1 受体激动剂的人在接下来的 5 至 7 年内患胰腺癌的风险没有显着差异（HR 0.50，95% CI 0.15-1.71）。他们在研究中指出，该模型针对年龄、性别、种族...
Dankner R, et al "Glucagon-like peptide-1 receptor agonists and pancreatic cancer risk in patients with type 2 diabetes" JAMA Netw Open 2023。
Ryder REJ. The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefits. Diabet Med 2013;30:1148-55. https://doi.org/10.1111/dme.12301Ryder RE. The potential risks of pancreatitis and...
近期,全球细胞和基因疗法(CGT)领域迎来系列进展。其中:科济药业靶向GPC3的CAR-T细胞治疗晚期肝细胞癌(HCC)的两例长期无病生存案例已在Cancer Communications发表并被录用为当期封面论文。Rocket Pharmaceuticals的基因疗法marnetegragene autotemcel获得美国FDA授予的优先审评资格,用于治疗严重I型白细胞粘附缺陷。本文将节选...
Monami M, Nreu B, Scatena A, et al. Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. Diabetes Obes Metab. 2017 Sep;19(9):12...
Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, consisting in abundant extracellular matrix settled by cancer associated fibroblasts (CAFs). Hereby, dysmetabolism and PDAC association was analyzed focusing on CAF functions.#PDAC development upon dysmetabolic conditions was investigated...
Potential concerns surrounding GLP-include pancreatitis, pancreatic cancer, colorectal cancer, suicide and other phycological effects, and thyroid cancer. Daniel J. Drucker, MD, from Mt. Sinai Hospital, said, for glucagon-like peptide-1 (GLP-1) medications, the brain is responsible for many of th...
However, an important clinical issue is whether these drugs increase the incidence of pancreatitis and pancreatic cancer. This paper reviews the physiology of GLP-1 including its synthesis, secretion and action of the peptide. Reported effects of the mimetic drugs on the exocrine pancreas in animal...
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary13,819,445,225visits served TheFreeDictionary Google ? Keyboard Word / Article Starts with Ends with Text EnglishEspañolDeutschFrançaisItalianoالعربية中文简体PolskiPortuguêsNederlandsNorskΕλληνικήРусский...
an increased risk of acute cholecystitis due to GLP1-RA treatment.[114] Animal model studies have suggested that GLP1-RAs may cause pancreatitis and exocrine dysplasia [115], however, in large randomized controlled trials, GLP1-RAs did not increase the risk of pancreatitis or pancreatic cancer....