2005年上市的Exenatide是GLP-1类似物相关药物中的第一个上市的药物(First-in-class),它需要病人每天打两针才能维持药效。 显然,对于一个长期药物,每天打两针对于病人来说是一个很大的身体和精神负担。所以Amylin没有止步不前,而是在Exenatide的基础上继续开发更长效的药物。 2012年,long-term Exenatide批准上市,药名...
Poon, T., Zhang, B., et al. 2006. Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus. Diabetes Obes Metab 8:419-428.
[24] Wang, X.H., Li, L., Holscher, C., Pan, Y.F., Chen, X.R., Qi, J.S. 2010. Val8-glucagon-like peptide-1 protects against Abeta1-40-induced impairment of hippocampal late-phase longterm potentiation and spatial learni...
GLP-1的作用之一是促使身体产生更多的胰岛素，从而降低血糖；大量GLP-1还会与大脑中减少食欲并发出饱腹感...
[6] Donahey, J.C., van Dijk, G., Woods, S.C., Seeley, R.J. 1998. Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats. Brain Res 779:75-83. [7] Turton, M.D., O'Shea, D., Gunn, I., Beak, S.A., Edwards, C....
1、Riddlesworth TD, Beck RW, Gal RL, et al. Optimal Sampling Duration for Continuous Glucose Monitoring to Determine Long-Term Glycemic Control. Diabetes Technol Ther. 2018 Apr;20(4):314-316. 2、Nathanson D, et al. SO 67-821. EASD Annual Meeting 2023. ...
[6] Donahey, J.C., van Dijk, G., Woods, S.C., Seeley, R.J. 1998. Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats. Brain Res 779:75-83. [7] Turton, M.D., O'Shea, D., Gunn, I., Beak, S.A., Edwards, C....
That said, limited supply of GLP-1s amid soaring demand, as well as the accompanying steep price tag, are constraints. The survey found that users of alternative weight-loss methods cited long-term health-oriented lifestyle goals, while GLP-1 users on average have not demonstrated significant ...
[16] Ratner, R.E., Maggs, D., Nielsen, L.L., Stonehouse, A.H., Poon, T., Zhang, B., et al. 2006. Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus. Diabetes Obes Metab 8...
GLP-1 and the long-term outcome of type 2 diabetes mellitus after Roux-en-Y gastric bypass surgery in morbidly obese subjects. Ann Surg 2013;257(5):894-9.Flores,L.,Delgado,etc.GLP-1 and the long-term outcome of type 2 diabetes mellitus after Roux-en-Y gastric bypass ...