2023年8月,《Frontiers in Endocrinology》杂志发表的一篇题为《Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review》的综述填补了空白。作者比较了10种胰高血糖素样肽-1受体激动剂(GLP-1RA...
2023年8月,《Frontiers in Endocrinology》杂志发表的一篇题为《Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review》的...
2023年8月,《Frontiers in Endocrinology》杂志发表的一篇题为《Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review》的综述填补了空白。作者比较了10种胰高血糖素样肽-1受体激动剂(GLP-1RA)...
D., and Haupt, A. (2018) Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial. The
一 ,GLP-1 受体激动剂发展史及分类 肠促胰 素 (Incretin)是从肠道分泌的可刺激胰 岛素 分泌的物质的统称.1964 年,Elrick 等发[5] 现 "肠促胰素效应 ",即在相同的血糖变化水平下 ,与静 脉注射葡萄糖 相比,口服葡萄糖可引起更多的胰岛 在保留其与 GLP-1 受体结合并发挥生物学效应的 同时使 其不易被 ...
Ismail H. Mitha, MD,Milan Zdravkovic, MD, PHD,Maria Düring, PHD,David R. Matthews, MD, and for the LEAD-2 Study Group. (2009). Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes.Diabetes Care,32(1): 84–90....
[13] Barnett, A.H., Burger, J., Johns, D., Brodows, R., Kendall, D.M., Roberts, A., et al. 2007. Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, rand...
[4] Rowland, N.E., Crews, E.C., Gentry, R.M. 1997. Comparison of Fos induced in rat brain by GLP-1 and amylin. Regul Pept 71:171-174. [5] Gil-Lozano, M., Perez-Tilve, D., Alvarez-Crespo, M., Martis, A., Fernandez, A.M., Catalina, P.A., et al. 2010. GLP-1(7...
OBJECTIVETo evaluate the comparative efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycaemic control, body weight, and lipid profile in adults with type 2 diabetes. DESIGNSystematic review and network meta-analysis. ...
结论:与甘精胰岛素相比,GLP-1类似物联合盐酸二甲双胍治疗T2DM,在降低2hPG、改善机体氧化应激、成本-效果方面更具优势。[关键词]GLP-1类似物;甘精胰岛素;盐酸二甲双胍;2型糖尿病;药物经济学[中图分类号]+5[文献标识码]A?[文章编号]1672-2809(2020)23-0000-03ComparisonoftheEfficacyandPharmacoeconomicsofGLP-1...