2021年6月14日,辉瑞全球研发中心的研究人员在国际顶尖医学期刊Nature Medicine在线发表了题为:Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial的临床试验论文。 这项1期临床试验表明,辉瑞公司开发的一种口服的小分子胰高血糖素样肽-1受体(...
阿尔兹海默症一直被称为“三型糖尿病”,而且中枢神经很多细胞都有GLP-1受体[4],说GLP-1可以改善阿尔兹海默症,我们一点都不需要惊讶,现在已经算2期临床效果显著,估计很快可以推进3期临床试验。而且因为多种GLP-1受体激动剂已经在过去10多年进行个多个3期临床试验,虽然都只针对糖尿病患者,但美国药监局对它的安全性...
2.Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab. 2001 Aug;86(8):3717-23. 3.GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PR...
[5] Vilsbøll, T et al. “Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.” Diabetes vol. 50,3 (2001): 609-13. doi:10.2337/diabetes.50.3.609 [6] Toft-Nielsen, M B et al. “Determinants of the impaired secretion of...
[2]Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in thetreatment of diabetes and obesity? [3]LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in p...
[ 6 ] Thrainsdottir I, Malmberg K, Olsson A, et al.Initial experience eith GLP-1 treatment on metabolic control and myocardial function in patients eith type 2 diabetes mellitus and heart failure[J]. Diabetes Vasc Dis Res. 2004;1(1):4...
4.Shweta Urva, Tamer Coskun, Mei Teng Loh, Yu Du, Melissa K Thomas, Sirel Gurbuz, Axel Haupt, Charles T Benson, Martha Hernandez-Illas, David A D’Alessio, Zvonko Milicevic, LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase...
CICR:钙诱导的钙释放;LCFA:长链脂肪酸;GLUT2:葡萄糖转运体2;GLP-1:胰高糖素样肽-1;GLP-2:胰高糖素样肽-2;OXM: 胃泌酸调节素;Trpc3:瞬时受体电位通道3;VDCC:电压门控钙通道;SGLT1:钠-葡萄糖共转运体1。 L-细胞对葡萄糖的摄取似乎是通过GLUT2和SGLT1两种途径介导的(图2)[32,34],其中电压SGLT1介...
[19] Ceriello, A., De Nigris, V., Pujadas, G., La Sala, L., Bonfigli, A.R., Testa, R., et al. 2016. The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes. Diabetes Res Clin Pract 114:64-68. ...
肠道和大脑细胞中含有前蛋白转化酶1（PC1），能够将proglucagon切割成Glicentin，Oxyntomodulin，GLP-1，GLP-2和IP-2，而胰岛细胞中含有前蛋白转化酶2（PC2），能够将proglucagon切割成Glucagon和MPGF（图1）[1]。从而发现这种神秘的物质是由肠道内分泌细胞如 L 细胞分泌的一种天然多肽降糖激素（即“肠促胰素”）[...