(GLP-1) agonists, incretin, liraglutide, exenatide, albiglutide, dulaglutide, type 1 diabetes mellitusAll English-language trials that examined glycemic end points using GLP-1 agonists in humans with T1DM were included.A total of 9 clinical trials examining the use of GLP-1 agonists in T1DM ...
27. Holst, J. J., Vilsboll, T., and Deacon, C. F. (2009) The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 297, 127-136 28. Mojsov, S., Heinrich, G., Wilson, I. B., Ravazzola, M., Orci, L., and Habener, J....
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2.Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab. 2001 Aug;86(8):3717-23. 3.GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PR...
GLP-1也可通过对β细胞的促胰岛素作用间接抑制胰高血糖素的分泌。正如近期的综述文章[34]所述,GLP-1既刺激δ细胞分泌生长抑素,又刺激β细胞分泌胰岛素、胰淀素、锌和γ氨基丁酸(GABA),所有这些都会抑制胰高血糖素的释放。在α-细胞来源的IN-R1-G9细胞系中,胰岛素通过激活PI3K来抑制胰高血糖素的释放。WortMannin...
1. Kesvadev J, et al. (2019) Pathophysiology of Type 2 Diabetes. In: Rodriguez-Saldana J.(eds) The Diabetes Textbook. Springer Cham. https://doi.org/10.1007/978-3-030-11B15-0_8. 声明:本文仅供医疗卫生专业人士了解最新医药资讯参考使用,不代表本平台观点。该等信息不能以任何方式取代专业的医...
CICR:钙诱导的钙释放;LCFA:长链脂肪酸;GLUT2:葡萄糖转运体2;GLP-1:胰高糖素样肽-1;GLP-2:胰高糖素样肽-2;OXM: 胃泌酸调节素;Trpc3:瞬时受体电位通道3;VDCC:电压门控钙通道;SGLT1:钠-葡萄糖共转运体1。 L-细胞对葡萄糖的摄取似乎是通过GLUT2和SGLT1两种途径介导的(图2)[32,34],其中电压SGLT1介...
[2] Ma, X. et al. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells". Journal of Diabetes. 2014, 6, 394–402. [3] Gautier, J. F. et al. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & Metabolism...
[1] Wester A, Shang Y, Toresson Grip E, et al. Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes. Gut. 2024 Jan 30. [...
GLP-1也可通过对β细胞的促胰岛素作用间接抑制胰高血糖素的分泌。正如近期的综述文章[34]所述,GLP-1既刺激δ细胞分泌生长抑素,又刺激β细胞分泌胰岛素、胰淀素、锌和Ƴ氨基丁酸(GABA),所有这些都会抑制胰高血糖素的释放。在α-细胞来源的IN-R1-G...