Type 1 diabetesGLP-1 agonistsObesityObjective Insulin therapy in Type 1 diabetes is associated with weight gain. Glucagon-like peptide 1 (GLP-1) agonists, which lower blood glucose and promote weight loss, may help reverse this trend and reduce hemoglobin A1C (A1C) levels. Methods Patients with...
[1]. Marso SP, Bain SC, Consoli A, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844. [2]. Gerstein HC, Colhoun HM, Dagenais GR, et al. D...
GLP-1类药物对睡眠、饮酒、尼古丁摄入等生活方式的改善有关 两项大型研究发现,与安慰剂相比,使用GIP/GLP-1受体双重激动剂tirzepatide可显著改善睡眠呼吸暂停综合征,无论患者是否佩戴气道正压通气装置治疗。 在糖尿病和肥胖治疗的研究中,有...
2021年6月14日,辉瑞全球研发中心的研究人员在国际顶尖医学期刊Nature Medicine在线发表了题为:Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial的临床试验论文。 这项1期临床试验表明,辉瑞公司开发的一种口服的小分子胰高血糖素样肽-1受体(...
GLP-1是一种由肠道L细胞分泌的激素,胰高血糖素样肽-1受体(Glucagon like peptide 1 receptor, GLP-1R)基因编码的蛋白为GLP-1激素的受体。GLP-1R在大脑、小肠、心脏、肺等组织中广泛表达,通过响应GLP-1和GLP-1类似物而内化,在胰岛素分泌的信号级联反应中发挥重要作用,同时在动物模型中的数据显示其具有神经保护作...
GLP-1 Receptor Agonist and SGLT2 Inhibitor Prescribing in People With Type 1 Diabetes Piaopiao Li, MS1,2; Zhiyan Li, MPH1; Elizabeth Staton, BA3; et al Guillermo E. Umpierrez, MD4; Georgia Davis, MD4; Hui Shao, MD, PhD1,5; Francisco J. Pasquel, MD, MPH1,4 Author Affi...
idiabetes”关注我们, 然后点右上角“…”菜单,选择“设为星标” 编者按: 自GLP-1被发现以来,它已然成为一种“多面手”激素——一个接一个代谢功能被人们发现,远远超出了其作为肠促胰素的经典定义。GLP-1的众多有益的多靶点作用使其逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药...
[1] Nauck, M. A., & Meier, J. J. (2019). MANAGEMENT OF ENDOCRINE DISEASE: Are all GLP-1 agonists equal in the treatment of type 2 diabetes?. European journal of endocrinology, 181(6), R211–R234.https://doi.org/10.1530/EJE-19-0566 ...
GLP-1 in Type 2 DiabetesGlp, NativePutative, Langerhans
3.GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study.Diabetes. 2015 Jul;64(7):2513-25. 4.GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol. ...