Dual activation of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R) has the potential to lead to an effective therapy for the treatment of diabetes and obesity. Here, we report the discovery of a series of peptides with dual activity on GLP-1R and GCGR that ...
该研究证明了每周一次的pemvidutide治疗能够显著降低LFC、肝脏炎症活动和体重,这表明pemvidutide可能是治疗MASH和肥胖症的有效方法。 参考文献:Harrison SA, Browne SK, Suschak JJ, et al. Effect of pemvidutide, a GLP-1/glucagon dual receptor ...
1. Sanyal AJ, Bedossa P, Fraessdorf M, et al. Glucagon and GLP-1 receptor dual agonist Survodutide improved liver histology in people with MASH and fibrosis: Results from a randomized, double-blind, placebo-con...
anagonistis amanufacturedsubstance that attaches to a cell receptor and causes the same action as the naturally occurring substance. In other words, GLP-1 medications bind to GLP receptors to trigger the effects (or roles) of the GLP-1 hormone. The higher the dose of the GLP-1 agonist, th...
GLP-1及其类似物 胰高血糖素样肽(Glucagon-Like Peptide,GLP-1)是由肠道分泌的一种内源性肽类激素,促进胰岛素分泌并抑制胰高血糖素的分泌。胰高血糖素样肽-1受体激动剂(Glucagon-Like Peptide-1 Receptor Agonist,GLP-1RA )是GLP-1经结构修饰所得的GLP-1类似物,提高体内活性GLP-1水平,降低血糖。 上游制备工...
1. Sanyal AJ, Bedossa P, Fraessdorf M, et al. Glucagon and GLP-1 receptor dual agonist Survodutide improved liver histology in people with MASH and fibrosis: Results from a randomized, double-blind, placebo-controlled phase 2 trial. EASL 2024 oral. ...
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that promotes healthy insulin signaling, regulates blood sugar levels, and suppresses appetite. Consequently, numerous GLP-1 receptor (GLP-1R) stimulating drugs have been developed and approved by the US Food and Drug Administration (FDA) ...
胰高血糖素样肽-1受体(Glucagon-like peptide-1 receptor,GLP-1R),是一种膜上的G蛋白偶联受体(GPCR)。人的GLP-1受体(hGLP-1R)基因位于人染色体6p21。结构上,典型特征是具有一个相对比较大的胞外域(ECD)和有α-螺旋束构成的7次跨膜核心域(TMD)(图1)[1]。该受体的N端胞外段长116个氨基酸残基,含有3对二...
*Definition: Global GLP-1 Receptor Agonist Market involves pharmaceutical products that mimic the effects of naturally occurring glucagon-like peptide-1 (GLP-1). GLP-1 receptor agonists work by stimulating the release of insulin from the pancreas in a glucose-dependent manner. These are used as ...
The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon receptor agonist, a linker and a hyaluronic acid hydrogel bearing -L1-L2-L-Y—R20 groups, wherein Y represents an GLP-1/Glucagon receptor agonist moiety; and -L is a linker...