The present invention relates to compounds having agonist activity in receptors of GLP-1 (glucagon like peptide 1) and GLP-2 (glucagon like peptide 2). This compound is particularly used in the prevention or treatment of intestinal damage and dysfunction, prevention of weight, and prevention or ...
目前，在GLP-1药物的DS生产工段中，对企业产能制约最大的是纯化工段，这是GLP-1药物生产过程中共性且核心的产能提升瓶颈问题。诺和诺德和礼来都相继加速布局产能，2024年2月，诺和诺德宣布斥资165亿美元收购CDMO巨头Catalent以提高生产能力，2024年5月，礼来宣布其在印第安纳州黎巴嫩生产基地新投资额达53亿美元。即便如此...
3. Liu QK. Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonist. Front Endocrinol, 2024, 15: 1431292. 4. Informa数据库, 检索日期: 2024年11月15日. 5. 药渡数据库, 检索日期: 2024年11月15日. ...
在代谢性疾病领域,继胰高糖素样肽-1(GLP-1)单靶点药物研发之后,GLP-1/葡萄糖依赖性促胰岛素多肽(GIP)双靶点无疑是新晋“宠儿”,通过作用于胰腺、脂肪组织和中枢神经系统等发挥降糖和减重等作用,具有重要的研发价值。除已上市的替...
为了解决这个问题,科学家们发明了一种叫做GLP-1受体激动剂(GLP-1 receptor agonist)的药物。这种药物能够模拟GLP-1的结构和功能,与人体内的GLP-1受体结合,从而发挥类似于GLP-1的作用。与GLP-1不同的是,GLP-1受体激动剂具有更长的半衰期,能够在人体内持续存在和发挥效果。因此,GLP-1受体激动剂能够有效地降低血糖...
GLP-1 receptoragonists. Incretin mimetics. GLP-1analogs. Glucagon:胰高血糖素 peptide:肽 agonist:激动剂 incretin:肠降血糖素 mimetic:/mɪˈmetɪk/类似物 analog:类似物 These medications are relatively new. The U.S. Food and Drug Administration (FDA) approved the first GLP-1 agonist (exena...
(生物谷Bioon.com) 参考文献 Eun Ran Kim et al. A GLP-1/GLP-2 receptor dual agonist to treat non-alcoholic steatohepatitis: targeting the gut-liver axis and microbiome. Hepatology. 2021 Nov 12. doi: 10.1002/hep.32235.
2.A dual agonist or pharmaceutically acceptable salt thereof according to claim 1 wherein:X2 is Aib;X5 is S or T;X7 is S or T;X8 is S or D;X10 is L;X11 is A or S;X15 is D or EX16 is E or G;X17 is Q or K;X19 is A or S;X20 is R;X21 is D or E;X24 is A, N...
A compound having agonist activity at the GLP-1 (glucagon-like-peptide 1) and GLP-2 (glucagon-like peptide 2) receptors, and a pharmaceutical composition containing the compound or
The invention relates to compounds having agonist activity at the GLP-1 (glucagon-like-peptide 1) and GLP-2 (glucagon-like peptide 2) receptors. The compounds find use, inter alia, in the prophylaxis or treatment of intestinal damage and dysfunction, regulation of body weight, and prophylaxis ...