ALT-801 (denoted as Compound 17) has also been shown to reduce blood glucose in the diabetic db/db mouse model at least as well as an equivalent dose of semaglutide20, suggesting that the glucoregulatory effects of the GLP-1R activation by ALT-801 were not disrupted by simultaneous agonism...
Conversely, the administration of caiapo at a dose of 5 g/KgBW over a period of 8 weeks substantially enhanced the beta cell mass by a two-fold increase when compared to the untreated diabetic control subjects (p < 0.05). The results indicated that increased dosages of the extract could ...