在非运动功能评估方面,MDS-UPDRS I 显示两组在非运动日常生活体验上无显著差异,MADRS 量表显示 GLP-1 激动剂组在抑郁改善方面有显著效果,与近期关于 GLP-1 激动剂抗抑郁作用的研究结果一致。但在生活质量评估上,PDQ-39 评分未显示出 GLP-1 激动剂组的优势,其平均差未超过生活质量改善的 MCID。 GLP-1 激动剂...
Dr Gabbay:The INHALE-3 study was in individuals with type 1 diabetes, and it compared long-acting insulin injection once a day and mealtime inhaled insulin vs other therapy—multidose insulin, insulin pump, even automate...
Food and Drug Administration (FDA), we expect to dose the first patient in the planned Part 3 of the trial during the third quarter of 2025, providing an interim data readout in or around mid-2026 and issuing top-line results in the second half of 2026." The Phase 1 trial is ...
Both forms of GLP-1 stimulated dose-dependent increases in intestinal somatostatin; secretion reached 643 _+ 126% of controls (p < 0.001) after treatment with 10-~ GLP-1736NH2, and 398 +_76% of controls (p < 0.001 ) after 10-6M GLP-1 t-36NN2.Thus, GLP-17-36NN2 was more ...
However, GLP-1 RAs can be combined with (basal) insulin in either free- or fixed-dose preparations. More recently developed agents, in particular semaglutide, are characterized by greater efficacy with respect to lowering plasma glucose as well as body weight. Since 2016, several cardiovascular (...
dose-dependent reduction in progenitor cell proliferation and improved migratory capacity towards the chemokine stromal-derived factor 1α (SDF-1α). Additionally, human CD34cells under high glucose treated with liraglutide demons...
Single doses of MEDI7219 dose-dependently reduced food intake over 24 h in lean C57Bl/6 J mice, with the high dose (3 nmol/kg) having comparable effects (–39.4%, P < 0.001) to an equivalent dose of semaglutide (Fig. 3a). Lower doses of MEDI7219 also reduced food intake (1...
Thus, yet another aspect of the invention provides glucagon co-agonist analogs that have higher activity at the glucagon receptor versus the GLP-1 receptor, glucagon co-agonist analogs that have approximately equivalent activity at both receptors, and glucagon co-agonist analogs that have higher ...
51.As is apparent from the above examples, amino acid residues may be identified by their full name, their one-letter code, and/or their three-letter code. These three ways are fully equivalent.The expressions “a position equivalent to” or “corresponding position” may be used to ...
(C) 10 nmol/kg/day doses. Data from equivalent dose-testing performed as part of the GEP44 (●) dose-escalation study were included in these figures to facilitate a qualitative comparison. Data shown are means ± standard error of the mean (SEM); *p < 0.05, **p < 0.01...