cardiovascular safety and benefits Michael Razavi1†, Ying‑Ying Wei2†, Xiao‑Quan Rao3* and Ji‑Xin Zhong2,4* Open Access Abstract Glucagon-like peptide-1 receptor ago
与天然GLP-1相比,利拉鲁肽氨基酸主干链上34位的赖氨酸(Lys)突变为精氨酸(Arg),进一步的索玛鲁肽第8位的丙氨酸(Ala)突变为非天然氨基酸2-甲基丙氨酸(Aib),可以避免多肽在体内被二肽基肽酶4(DPP4)酶切失活延长半衰期。在研究脂肪酸侧链时,着重研究了连接子、脂肪酸...
DPP4是一种体内的酶,也就是酵素。它主要的作用是在分解体内的蛋白质!其中一种被DPP4分解的蛋白质叫做GLP─1,它是由肠道细胞分泌的荷尔蒙,GLP-1可以通过可以刺激胰岛素、抑制升糖素、抑制胃排空和让胰岛细胞重生的方式来降低血糖。导致DPP4失活从而不分解GLP-1的DPP4抑制剂已经成为治疗糖尿病的主攻方向之一。 在...
The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]. The expression of GLP-1 has been ...
1. Intestinal L cells-derived GLP-1 induce insulin secretion in response to meal intake. 2. Insulinotropic potency of GLP-1 decrease in T2DM. 3. GLP-1 receptor agonists and DPP4-inhibitor direct the T2DM therapies. 4. Increasing the endogenous production of GLP-1 through increasing the L-cel...
We found GLP-1R expression was increased after DPP-4 inhibition, and it is thought to be associated with ligand-receptor interaction. It is well established, in cellular signaling fields, that the level of various cellular receptors is proportionally related to the extracellular level of their cogn...
To our knowledge, only 1 review has addressed the effects of different nutrients on GLP-1 secretion (15); however, the effect of protein ingestion in humans was not discussed, as well as particular reference to protein forms and interaction with calcium, which is crucial for practical ...
1.3. Herb Drug Interaction Herb Drug interaction, which generally involves Cytochrome P450 and various other means, can be neutral, beneficial and hazardous, by altering pharmacokinetics and pharmacodynamics of co-administered drugs for mitigation of same or different health issues (Thikekar et al., ...
The gastrointestinal tract transmits feeding-regulatory signals to the brain via neuronal and hormonal pathways. Here we studied the interaction between the orexigenic gastric peptide, ghrelin, and the anorectic intestinal peptide, glucagon-like peptide 1 (GLP-1), in terms of feeding regulation via ...
Kutina, A. V., Golosova, D. V., Marina, A. S., Shakhmatova, E. I. & Natochin, Y. V. Role of vasopressin in the regulation of renal sodium excretion: interaction with glucagon-like peptide-1.J Neuroendocrinol.http://dx.doi.org/10.1111/jne.12367(2016). ...