Combination therapies of DPP4 inhibitors and GLP1 analogues with insulin in type 2 diabetic patients: a systematic review. Curr Vasc Phar- macol 2013; 11: 992-1000.Rizos EC, Ntzani EE, Papanas N, et al.-- Combination therapies of DPP4 inhibitors and GLP1 analogues with insulin in...
kidney disease. As GLP-1 has been implicated as a mediator in the putative gut–renal axis (a rapid-acting feed-forward loop that regulates postprandial fluid and electrolyte homeostasis), direct actions on the kidney have been proposed. Here, we review the role of GLP-1 and the actions of...
induced MI in wild type mice and in mice treated with the DPP-4i inhibitor sitagliptin or with genetic deletion of DPP-4 (dpp4−/−) after induction of diabetes with high-fat diet and streptozotocin. Dpp4−/− mice showed an increased survival after MI compared with dpp4+/+ mice ...
GLP-1 和 GLP-2 则存在于胰高血糖素前驱体后半的结构中。GLP-1由37个氨基酸组成,有2种生物活性形式,分别为 GLP-1(7-37)和GLP-1(7-36)酰胺。两者都存在于小肠下部、胰脏和下丘脑中,GLP-1(7-36)酰胺在下丘脑中占免疫反应 GLP-1(IR-GLP-1)总量的 55-94%,在小肠中占 27-73%。但在胰脏中只有极...
1. Intestinal L cells-derived GLP-1 induce insulin secretion in response to meal intake. 2. Insulinotropic potency of GLP-1 decrease in T2DM. 3. GLP-1 receptor agonists and DPP4-inhibitor direct the T2DM therapies. 4. Increasing the endogenous production of GLP-1 through increasing the L-cel...
Therefore, this narrative review focuses on the incretin hormone GLP-1, and the research surrounding protein- and/or calcium-mediated GLP-1 secretion in humans. The potential mechanisms by which the combination of protein and calcium might enhance GLP-1 secretion are also discussed, alongside ...
1. Intestinal L cells-derived GLP-1 induce insulin secretion in response to meal intake. 2. Insulinotropic potency of GLP-1 decrease in T2DM. 3. GLP-1 receptor agonists and DPP4-inhibitor direct the T2DM therapies. 4. Increasing the endogenous production of GLP-1 through increasing the L...
Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and is a significant risk factor for increased morbidity and mortality. In contrast, GLP-1 receptor (GLP-1R) activation has been shown to confer both renal and cardiovascular protection, though its relationship with CKD ...
1份 ◆交叉反应 ※交差率是1,000 pg/mL浓度时的数据 动物类型 对象物质 反应性和反应率(%) Mouse/Rat GLP-1(7-36)amide 100 GLP-1(7-37) < 0.1 GLP-1(1-37) ― GLP-1(9-36)amide ― GLP-2 ― Glucagon(1-29) ― Insulin ―
(2011) “Protein-excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development,” Adv. Drug Deliv. Rev. 63:1118-1159. Kazakos et al. (2011) “Incretin effect: GLP-1, GIP, DPP4,” Diabetes Res Clin Pract. 93(Suppl 1):S32-S36. et al. (2011...