While the studies supporting these benefits were not initially focused on kidney health and included patients with low kidney risk, they suggest a link between GLP-1 RAs treatment and kidney protection, especially for type 2 diabetes patients with CKD18. Building upon these findings, we conducted ...
1. Selvarajah V, Robertson D, Hansen L, et al. A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney dis...
GLP-1 is a gut-derived insulin agonist with the ability to suppress glucagon release and stimulate insulin secretion through targeting α-cells and β-cells, respectively [5]. Likewise, GLP-1RAs can lower postprandial glycemia predominantly by slowing gastric emptying and promoting weight loss [6,...
【Key words 】 Diabetes mellitus, type 2; Atherosclerotic cardiovascular disease; Glucagon‑likepeptide‑1 receptor agonist 胰高糖素样肽‐1受体激动剂(GLP‐1RA)通过 的食欲抑制来减少进食量,从而达到降低血糖的作 模拟天然胰高糖素样肽‐1(GLP‐1)激活GLP‐1受 用。GLP‐1RA不仅降糖效果显著,单独使用...
have beneficial effects in the kidney. We found that GLP-1R was expressed in the rat kidney and importantly, its expression was not altered by maternal obesity, diet-induced obesity or Exendin-4 treatment. It was previously shown that treatment with the GLP-1R agonist liraglutide suppresses the...
近年来研究提示,胰高血糖素样肽-1受体激动剂对ORG有一定的保护作用。 关键词: 肥胖相关性肾病;胰高血糖素样肽-1;肾脏疾病 ABSTRACT Obesity-related glomerulopathy (ORG) is a renal lesion caused by insulin resistance and chronic inflammation caused by obesity and metabolic syndrome. The mechanisms are ...
Suspected clinical impacts of GLP-1RAs, SGLT2is, and finerenone oncardiovascular and kidney outcomes. CV, cardiovascular; GLP-1RA, glucagon-like peptide-1 receptor agonist; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; MI, myocardial inf...
A meta-analysis of the therapeutic effects of glucagon-like peptide-1 agonist in heart failure Int J Pept, 2012 (2012), pp. 1-7 CrossrefGoogle Scholar 38 K.B. Margulies, A.F. Hernandez, M.M. Redfield, et al. Effects of liraglutide on clinical stability among patients with advanced hea...
A. et al. Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder. Drug Alcohol Depend. 221, 108614 (2021). CAS PubMed PubMed Central Google Scholar Dixit, T. S., Sharma, A. N., Lucot, J...
Suspected clinical impacts of GLP-1RAs, SGLT2is, and finerenone oncardiovascular and kidney outcomes. CV, cardiovascular; GLP-1RA, glucagon-like peptide-1 receptor agonist; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; MI, myocardial inf...