glomerular parietal epithelial cellsEMTstem cell phenotyperenal progenitorsmetastable cellsGlomerular parietal epithelial cells (GPECs) are known to revert to embryonic phenotype in response to renal injury. However, the mechanism of de-differentiation in GPECs and the underlying cellular processes are not...
Glomerular parietal epithelial cells (GPECs) are known to revert to embryonic phenotype in response to renal injury. However, the mechanism of de-differentiation in GPECs and the underlying cellular processes are not fully understood. In the present study, we show that cultured GPECs of adult mu...
The formation of tight junctions by parietal epithelial cells (PECs) creates a barrier that confines proteins to the Bowman's space, say the researchers of a new study. Disruption of these tight junctions increases the permeability of this barrier and, according to the study authors, may...
The glomerular parietal epithelial cells (PECs) have aroused an increasing attention recently. The proliferation of PECs is the main feature of crescentic glomerulonephritis; besides that, in the past decade, PEC activation has been identified in several types of noninflammatory glomerulonephropathies,...
Studies have shown in several diseases initially affecting podocytes, that the neighboring glomerular parietal epithelial cells (PECs) are secondarily involved. The PEC response might be reparative under certain circumstances, yet injurious under others. The factors governing these are not well understood....
Very little is known about the function of glomerular parietal epithelial cells (PECs). In this study, we performed genome-wide expression analysis on PEC-enriched capsulated vs. PEC-deprived decapsulated rat glomeruli to determine the transcriptional state of PECs under normal conditions. We ...
The results suggest an important, albeit controversial, role of parietal epithelial cells in this context.doi:10.1038/nrneph.2014.163Saritas, TurgayMoeller, Marcus J.Nature Reviews NephrologySaritas T,Moeller MJ.Glomerular disease:pre-eclampsia,podocyturia and the role of parietal epithelial cells[J]....
The glycoprotein CD44 is barely detected in normal mouse and human glomeruli, but is increased in glomerular parietal epithelial cells following podocyte injury in focal segmental glomerulosclerosis (FSGS). To determine the biological role and regulation of CD44 in these cells, we employed an in vivo...
Glomerular Parietal Epithelial Cell Expression of Cathepsin C Increases in Tg26 Mouse Model of HIV-Associated Nephropathy (HIVAN)doi:10.1681/ASN.20233411S1960dMichelle T. BaratiJon B. KleinMichael MerchantAmerican Society of NephrologyJournal of the American Society of Nephrology...
The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capil