stem cell phenotyperenal progenitorsmetastable cellsGlomerular parietal epithelial cells (GPECs) are known to revert to embryonic phenotype in response to renal injury. However, the mechanism of de-differentiation in GPECs and the underlying cellular processes are not fully understood. In the present ...
The formation of tight junctions by parietal epithelial cells (PECs) creates a barrier that confines proteins to the Bowman's space, say the researchers of a new study. Disruption of these tight junctions increases the permeability of this barrier and, according to the study authors, may...
The present study would improve our understanding on epithelial cell plasticity, furthering our knowledge of its role in renal repair and regeneration. 展开 关键词: glomerular parietal epithelial cells EMT stem cell phenotype renal progenitors metastable cells ...
Transcriptional landscape of glomerular parietal epithelial cells.doi:10.1371/journal.pone.0105289Very little is known about the function of glomerular parietal epithelial cells (PECs). In this study, we performed genome-wide expression analysis on PEC-enriched capsulated vs. PEC-deprived decapsulated ...
The glomerular parietal epithelial cells (PECs) have aroused an increasing attention recently. The proliferation of PECs is the main feature of crescentic glomerulonephritis; besides that, in the past decade, PEC activation has been identified in several types of noninflammatory glomerulonephropathies,...
Mouse parietal epithelial cells in culture A previously generated and characterized32 conditionally immortalized mouse glomerular parietal epithelial cell line was used for in vitro experiments. Cells were plated on Primaria dishes (Corning Inc., Corning, NY) coated with collagen type I (BD Bioscience,...
PEC: Parietal epithelial cell FSGS: Focal segmental glomerulosclerosis EMT: Epithelial-to-mesenchymal transformation α-SMA: Alpha-smooth muscle actin.References Marshall CB, Shankland SJ: Cell cycle regulatory proteins in podocyte health and disease. Nephron Exp Nephrol. 2007, 106 (2): e51-e59...
This study preliminarily investigated whether CD44 immunostaining in glomerular parietal epithelial cells (PECs) is a prognostic marker in pediatric FSGS. METHODS: In this retrospective study, 26 patients with FSGS, biopsied from 1985 to 2010, were evaluated. Immunohistochemistry for CD44 was performed ...
The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capil
Fatima H, Moeller MJ, Smeets B, Yang HC, D’Agati VD, Alpers CE, Fogo AB (2012) Parietal epithelial cell activation marker in early recurrence of FSGS in the transplant. Clin J Am Soc Nephrol 7:1852–1858 Article PubMed PubMed Central Google Scholar Hodgkins KS, Schnaper HW (2012) ...