With subsequent once daily dosing of GLIPIZIDE XL, plasma glipizide concentrations are maintained throughout the 24 hour dosing interval with less peak to trough fluctuation than that observed with twice daily dosing of immediate release glipizide. The mean relative bioavailability of glipizide in 21 ...
Effects of once-daily and twice- daily dosing on adherence with prescribed glipizide oral therapy for type 2 diabetes. South Med J 2002;95:68-71.Dezii CM, Kawabata H, Tran M. Effects of once-daily and twice-daily dosing on adherence with prescribed glipizide oral therapy for type 2 ...
Cautious dosing recommended.Geriatric PatientsConventional tablets: Initially, 2.5 mg daily.Initially, 5 mg (extended-release tablets) may be used.Use conservative initial and maintenance dosage of glipizide-containing formulations.Adjust dosage carefully. Any dosage adjustment of glipizide in fixed ...
compared to immediate release Glucotrol (10 mg given twice daily), was 90% at steady-state. Steady-state plasma concentrations were achieved by at least the fifth day of dosing with GLUCOTROL XL in 21 males with type 2 diabetes mellitus and patients...
dosing frequencyTwo cross-over studies were carried out in 23 patients with Type 2 diabetes, to examine whether glipizide, a potent sulphonylurea with fast and complete absorption and rapid elimination (t1/2 less than 5 h), can be given once-daily without loss of therapeutic effect. In both...