Several factors contribute to this, including (i) the blood–brain barrier (BBB) preventing the entry of therapeutic molecules, (ii) the low immunogenicity of gliomas limiting the initiation of immune responses, and (iii) the immunosuppressive microenvironment inhibiting the activity of effector T ...
METHODS. Optum Market Clarity Data were used to identify patients aged 鈮 18 years with an ICD-10 code for brain neoplasm, 鈮 1 physician notes, and with evidence of pLGG recorded between January 1, 2017 and June 30, 2018. Outcomes including health characteristics, HRU, medications, and ...
Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates [1]. Overall, the broad category of gliomas (ICD-O-3 histology codes 9380–9384 and 9391–9460) represents approximately 24.5% of all primary brain tumors and 80.9% of all mal...
First, we tested the expression ofLnc-THORin human glioma tissues. As described in our previous studies21, a total of five pairs of human glioma tissues (“T”) and paired surrounding normal brain tissues (“N”) were analyzed, and qPCR assay results in Fig.1ashow thatLnc-THORlevels are ...
Although TROY has been identified as a member of TNFR superfamily [10, 11], the downstream effects of TROY receptor binding is not well elucidated. To deepen an insight into the downstream signaling of TROY, we performed a proteomic analysis of the binding partners of TROY-ICD. The intracellul...
74 Regarding the treatment of brain tumors, this method is optimized for application into solid tumor tissue, however not into a resection cavity after surgery. The problem that emerges from here is that primary tumors are usually treated by neurosurgery that is the standard of care. Thus, at ...
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma Nat. Rev. Cancer, 10 (2010), pp. 319-331 CrossrefView in ScopusGoogle Scholar Jögi et al., 2002 A. Jögi, I. Øra, H. Nilsson, A. Lindeheim, Y. Makino, L. Poellinger, H. Axels...
et al: Spectroscopy鄄 of radiation therapy plus procarbazine, lomustine, and supported frame鄄ba sed image鄄gu ided stereotactic biopsy vincristine chemotherapy for supratentorial adult low鄄 of parenchymal brain lesions: comparative evaluation of grade glioma: Initial results of RTOG 9802.J [J]. ...
involvement of TET1 in glioma growth in humans. The levels of 5-hydroxymethyl cytosine were strongly depleted in astrocytomas compared to a normal brain9. In a study examining the Cancer Genome Atlas, the levels of 5hmC were reported to be associated with poor survival in anaplastic glioma10...
A major obstacle to cure this devastating type of brain tumours is attributed to its highly invasive nature. In fact, glioma cells have a remarkable ability to infiltrate the surrounding brain tissue and migrate long distances away from the tumour bed, which enables them to escape surgical ...