HIF-1α: Hypoxia-inducible factor 1α HLA: Human leukocyte antigen HMW-HA: High-molecular weight hyaluronic acid HS-TEXs: Exosomes that are highly enriched in HSP70 ICAM-1: Intercellular adhesion molecule ICD: Immunogenic cell death ICG: Indocyanine green ICI: Immune checkpoint inhibitor...
He died 24 months after diagnosis. Because of the observation of spreading disease, JV is now further treated with maintenance ICD immunotherapy using local modulated electrohyperthermia to the brain and to the upper and lower spine. She shows no evidence of progressive disease after >25 months. ...
The potential effect ofLnc-THORon glioma cell apoptosis was studied. As shown, in the A172 cells withLnc-THORshRNA (“Seq-1/-2”) or Lnc-THOR-KO construct (“KO-THOR” cells, see Fig.2), the activities of caspase-3 and caspase-9 were significantly increased (compared to control A172...
成人低级别胶质瘤的治疗 表 1 WHO 中枢神经系统肿瘤分类 渊2007 年冤 肿瘤分类 ICD鄄O WHO 分级 星形细胞瘤 弥漫性星形细胞瘤 渊diffuse astrocytoma冤 纤维型 渊fibrillary 冤 *9420/3 域 肥胖细胞型渊gemistocytic冤 *94 11/3 域 原浆型 渊protoplasmic 冤 *94 10/3 域 少突胶质细胞肿瘤 少突胶质细胞瘤...
Baseline characteristics of the study population are described in Table 1. Diagnosis was based on histology in 140 (95%) gliomas, 81 (59%) meningiomas and 18 (46%) schwannomas, and the remaining tumours were diagnosed based on radiology. Tumours incidentally found at autopsy were excluded from...
Gliomas comprise an aggressive group of heterogeneous tumours with poor 5–year survival: vague initial symptoms predispose to delayed diagnosis with subsequent poor prognosis. Invasive biopsy and current diagnostic challenges emphasise the need to identify novel, specific and non–invasive early–diagnostic...
Hypoxia-inducible factor 1α HLA: Human leukocyte antigen HMW-HA: High-molecular weight hyaluronic acid HS-TEXs: Exosomes that are highly enriched in HSP70 ICAM-1: Intercellular adhesion molecule ICD: Immunogenic cell death ICG: Indocyanine green ...
Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates [1]. Overall, the broad category of gliomas (ICD-O-3 histology codes 9380–9384 and 9391–9460) represents approximately 24.5% of all primary brain tumors and 80.9% of all mal...
Presence of seizures was determined by anti-epileptic drug fills within one year following LGG diagnosis. Patients with new onset of MHDs were identified using ICD-9 codes for MHDs and psychotropic drug fills in the 12 months post-LGG diagnosis period. Unadjusted odds ratios measured associations...
The prospective design ensured that self-reported information on smoking and alcohol intake was not influenced by diagnosis of glioma. In addition, the relatively large number of glioma cases allowed for a precise investigation of risk by sex and across a relatively wide range of total alcohol, ...