Secondary glioblastoma.This type usually develops from a low-grade glioma – a type of tumor found in the brain or spinal cord. It’s more likely to affect younger people, and it’s usually in the frontal lobe of the brain. The survival rate for this type tends to be better than for ...
Epidemiology:Glioblastoma is considered the most aggressive malignant tumor with a rare incidence rate (3.19 per 100,000 people per annum); however, its poor diagnosis and minimal survival rate make it a significant health issue[4, 5]. After the diagnosis of GBM, most of the patients survive ...
Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J. Neuropathol. Exp. Neurol. 64, 479–489 (2005). Article CAS PubMed Google Scholar Louis, D. N. et al. The World Health Organization classification of tumours of the...
Glioblastoma (GB 鈥 WHO grade IV) is the most frequent and lethal primary brain tumour with median overall survival of 7鈥 15 months after diagnosis. As in other cancer research areas, an overwhelming amount of pre-clinical research acquisitions in the GB field have not been translated to ...
Glioblastoma (GBM) is the most common primary brain tumor and among the deadliest of human cancers. Despite advances in surgery, radiation and chemotherapy, survival of patients affected by GBM remains dismal (~15 months after diagnosis)1,2,3. Clearly, better treatment options, and identification...
Kaplan-Meier survival curves generated with Rembrandt [1] -derived patient data also showed a correlation between higher STAT6 expression and decreased survival of glioma patients. Finally, GBM cells in which STAT6 had been silenced with shRNA exhibited markedly decreased rates of proliferation and ...
[1]. This aggressive malignant type of primary brain tumor has swift and devastating consequences resulting in a median survival after diagnosis of one year [2,3,2]. Primary glioblastoma has a higher incidence in Caucasian men than in other racial and gender groups [4] although these ...
et al. Gene expression profiling of gliomas strongly predicts survival. Cancer Res. 64, 6503–6510 (2004). Article CAS PubMed Google Scholar Shirahata, M. et al. Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis. Clin. Cancer Res. 13...
(Fig.S2B). Furthermore, the analysis ofFMR1mRNA levels in GBM tissues used for the IHC experiment, revealed a positive association betweenFMR1mRNA expression and patient survival rates (Fig.S2C). Consistently, a meta-analysis ofFMR1mRNA expression in the TCGA GBM database revealed that patients ...
Kaplan-Meier survival curves generated with Rembrandt [1] -derived patient data also showed a correlation between higher STAT6 expression and decreased survival of glioma patients. Finally, GBM cells in which STAT6 had been silenced with shRNA exhibited markedly decreased rates of proliferation and ...