This paper presents an atypical case of a patient with brain tumor of the glioblastoma multiforme (GBM) type who achieved a 5-year survival. Some general information is provided including epidemiology, diagnostic and treatment procedures (surgery and radio-chemo-therapy), and prognosis of survival ...
Stage 4 glioblastoma multiforme is the last stage of brain tumor. For the patient in IV stage of glioblastoma multiforme, the rate of survival diminishes. With treatment, the patient can hardly live two years as the disease is not curable. In this stage, the tumor travels and spreads in a...
W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008). This comprehensive analysis discovered various genes that were not previously known to be altered in GBM; most notably, recurrent hotspot mutations in IDH1. Article CAS PubMed PubMed ...
Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized in preclinical
BACKGROUNDSocial factors influence cancer treatment choices, potentially affecting patient survival. In the current study, the authors studied the interrelations between marital status, treatment received, and survival in patients with glioblastoma multiforme (GM), using population-based data.METHODSThe data...
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Herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV) gene therapy was performed in five cases of recurrent glioblastoma multiforme. The mean age of cases, three males and two females, was 60 +/- 5 years old. All of the tumors were confirmed pathologically as glioblastoma multiforme an...
Keywords: glioblastoma, minichromosome maintenance protein 5, chemotherapeutic drug resistance Introduction Gliomas are categorized into four grades (Grade I, II, III, and IV) based on their malignant nature in pathologic diagnosis, with glioblastoma multiforme (GBM) identified as Grade IV gliomas. ...
The 1- and 2-year OS rates were 71.2% and 26.3%, respectively. Adjuvant TMZ chemotherapy was significantly predictive of OS on multivariate analysis. Late toxicity included 7 cases of Grade 3-4 radiation necrosis. Hypo-IMRT with MET-PET data appeared to result in favorable survival outcomes ...
Glioblastoma (GBM) represents the most common and aggressive form of malignant tumor in the central nervous system, characterized by a low five-year survival rate of 6.8%1. Despite advancements in diagnostic techniques and treatment modalities, therapeutic resistance and tumor recurrence continue to cha...