U87 glioblastoma cells were obtained from ATCC (Manassas, VA, USA; RRID:CVCL_0022), and U87 cells expressing iRFP720 were kindly provided by Mischel PS (Department of Pathology, Stanford University). GSPT1-KO U87 cell lines were established using a genome-editing method. Briefly, TrueGuide syn...
While two-inhibitor strategies have been evaluated, such as the combination of erlotinib and sorafenib for the treatment of brain tumors (Peereboom et al., 2013), three-inhibitor clinical trials have not yet been initiated. However, an ongoing phase I trial is evaluating the safety of combining...
approved for use in the treatment of one condition for the treatment of another (we differentiate this from drug repositioning, which we will use to refer to the practice of finding a new use for drugs that had some other intended purpose in clinical trials, but do not have regulatory ...
Liu, Tiffany T.Stanford UnivAchrol, Achal S.Stanford UnivMitchell, Lex A.Stanford UnivRodriguez, Scott A.Stanford UnivFeroze, AbdullahStanford UnivIv, MichaelStanford UnivKim, ChristineStanford UnivChaudhary, NavjotStanford UnivGevaert, OlivierStanford Ctr Biomed Informat ResStuart, Josh M....
DA Vasquez-Medrano1 and JM Brown*,1 1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, 269 Campus Drive West, CCSR Room 1255, Stanford, CA94305, USA Local recurrence of glioblastomas is a major cause of patient mortality after definitive treatment. ...
We hope these advances will improve patient stratification for clinical trials and lead, ultimately, to personalized treatments. Consortia The members of the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium are Anupriya Agarwal, Mitual Amin, Eunkyung An, Matthew L. Anderson, David...
oncolytic viruses; glioblastoma; clinical trials; biomarkers; personalized oncolyticvirotherapy1. Introduction Oncolytic viral therapy or virotherapy is a form of immunotherapy showing promising results for cancers with poor prognosis [1]. In this approach, oncolytic viruses (OVs) are employed to kill ...
HudsonAlpha Institute/Stanford University Devin M. Absher , Jun Z. Li , Audrey Southwick , Shannon Brady , Amita Aggarwal , Tisha Chung , Gavin Sherlock , James D. Brooks & Richard M. Myers Lawrence Berkeley National Laboratory Paul T. Spellman , Elizabeth Purdom , Lakshmi R. Jakkula , An...
heart diseases, active peptic ulcer disease or gastritis, adverse events from prior anti-cancer therapy that have not resolved to Grade ≤ 1 (except for alopecia), major surgical procedures in the preceding 4 weeks, pregnant or nursing women and involved in other clinical trials within 30 days....
Raw data were normalized to the result of normal brain RNA and analyzed using the sig- nificance analysis of microarrays (SAM, version 2.1, http:// www-stat.stanford.edu/Btibs/SAM, Stanford University, CA, USA) software. For transfected cells, reverse transcription (RT) reaction was ...