administration timeplasma glucoseinsulinc-peptideThe effect of altering the timing of gliclazide administration in relation to a meal was studied in ten type 2 (non-insulin dependent) chronically treated diabetics. Gliclazide was given 30 min before, at the start of and 30 min after breakfast or ...
It was developed as part of an effort to create more effective and selective sulfonylurea drugs to control blood sugar levels in people with type 2 diabetes. Over time, gliclazide has become one of the most widely prescribed medications for managing diabetes. Its applications extend beyond diabetes...
PLGA polymer biodegradation time varies from days to months depending on its molecular weight and ratio of lactic-glycolide copolymers composition. PLGA, which functions as a protective polymer, forms a surface grafted polymeric molecule, aids in the incorporation of therapeutic agents for their ...
The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, ...
(23% decrease at 60 min) in contrast to the normoglycaemic animals (36% decrease at 60 min), at later times, the intensity of this hypoglycaemizing effect of gliclazide persisted in the hyperglycaemic animals, while in the normoglycaemic ones, a reversal of the hypoglycaemizing effect ...
hypoglycemic effectionic liquidtransdermal drug deliveryIonic liquids (IL) technology provides a useful platform to achieve the topical delivery of therapeutic agents, because of its capability to improve skin permeability. While the majority of the researches aimed to achieve local action by topical IL...
Blood samples were collected at desired intervals of time and analyzed for blood glucose by GOD/POD method.Sandeep J JaybhayeBabita B. LodhiShri Bhagwan
The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, ...
TCF7L2 rs7903146 C/T genotype was identified by real-time PCR with subsequent melting curve analysis. Analyses using the dominant genetic model showed significantly higher effect of gliclazide in the CC genotype group in comparison with combined CT + TT genotype group (1.32 ± 0.15% versus 0.73...
A Symmetry C18, 50x4.6, 5u, a mobile phase composed of Acetonitrile: 25mM Potassium dihydrogen orthophosphate (pH-6.5) (50:50 v/v), and a flow rate of 0.6 mL/min were employed, and the total run time was 3.0 min. The method was validated for accuracy, precision, linearity, ...