It was developed as part of an effort to create more effective and selective sulfonylurea drugs to control blood sugar levels in people with type 2 diabetes. Over time, gliclazide has become one of the most widely prescribed medications for managing diabetes. Its applications extend beyond diabetes...
Additionally, the stimulatory effect of gliclazide MR on insulin secretion falls with falling glucose levels (Gregorio et al., 1992). The experts also noted that weight gain could be due to defensive eating in patients who have HEs. When HEs are few or avoided, weight gain is less (Ahrén,...
Blood samples were collected at desired intervals of time and analyzed for blood glucose by GOD/POD method.Sandeep J JaybhayeBabita B. LodhiShri Bhagwan
PLGA polymer biodegradation time varies from days to months depending on its molecular weight and ratio of lactic-glycolide copolymers composition. PLGA, which functions as a protective polymer, forms a surface grafted polymeric molecule, aids in the incorporation of therapeutic agents for their ...
The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, ...
Gliclazide bioavailability was totally different for two formulations in both healthy and diabetic rats based on area under the curve (AUC), time to peak concentration (tmax) and peak concentration (Cmax). Reduction of blood glucose level was significantly higher after the administration of IR than...
The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, ...
A Symmetry C18, 50x4.6, 5u, a mobile phase composed of Acetonitrile: 25mM Potassium dihydrogen orthophosphate (pH-6.5) (50:50 v/v), and a flow rate of 0.6 mL/min were employed, and the total run time was 3.0 min. The method was validated for accuracy, precision, linearity, ...
TCF7L2 rs7903146 C/T genotype was identified by real-time PCR with subsequent melting curve analysis. Analyses using the dominant genetic model showed significantly higher effect of gliclazide in the CC genotype group in comparison with combined CT + TT genotype group (1.32 ± 0.15% versus 0.73...
we considered different formulation and process variables, such as the selection of the solvent system, solvent–antisolvent phase ratio, and type and concentration of stabilizer used. After adjusting one parameter at a time while keeping the other parameters constant, the effect of the aforementioned...