Glial cells are now recognized as functional components of the nervous system rather than being regarded as structural “glue” holding the nervous system together [1] In vitro studies of primary cultures of glial cells have been an important tool to understand the metabolic capabilities of these c...
Fig. 2: Intercellular communication between motor neurons, astrocytes, microglia and oligodendrocytes is altered between SOD1G93A and WT cells at peri-symptomatic onset stage of disease. Circos plots88 of the top putative ligand–receptor interactions and heatmaps of top ligands’ Pearson correlation...
We find that while the tumor core enriches for oligodendrocyte precursor-like cells, radial glial stem-like (RG-like) cells are enriched in the neuron-rich invasive niche in both DMG and GBM. Further, we identify niche-specific regulatory programs for RG-like cells, and functionally confirm ...
A higher number of glial cells were recruited to RGNs of fibrillar versus dense-core plaques despite both having similar outer boundaries defined by reactive astrocytes. Interestingly, fibrillar plaques were associated with greater pathology of surrounding neurons28, suggesting that an especially dynamic ...
Infected cells are necrotic (asterisk). The microscopic picture presents hematoxylin and eosin staining. Although we are far from understanding the exact molecular pathways underlying neuron–glia interactions in the virus-infected CNS, RABV and HSV both modulate the gene expression of signaling ...
Unique attention has been given to TLR4 signaling: this is seemingly associated with METH induced activation of glial cells in hippocampus [44], increased DA in the NAc shell [36], enhanced cytokine expression in the cortex [37], and reduced pro-inflammatory mediators in microglia-like cells ...