The main glial cells of the PNS and CNS can be identified both in situ and in culture by the use of combinations of different antibodies which act as markers for the different cell types. The particular combination of antibodies chosen depends very much on the developmental stage and anatomical...
Myelin production is the major function of oligodendrocytes in the CNS and Schwann cells in the PNS of vertebrates. The appearance of myelin correlates with jaw development, which suggests that it is a recent invention, from an evolutionary point of view [2]. Myelin-associated proteins are used ...
Myelin production is the major function of oligodendrocytes in the CNS and Schwann cells in the PNS of vertebrates. The appearance of myelin correlates with jaw development, which suggests that it is a recent invention, from an evolutionary point of view [2]. Myelin-associated proteins are used ...
The CNS-PNS transitional zone of rat cervical ventral rootlets develops in two stages: first, axon segregation, then transitional node formation. This ultrastructural study examines the former. Material was prepared by standard methods. Shortly after they grow out from the neural tube, ventral motone...
However, non-neuronal cells of the PNS have also been associated with wound healing. In particular, cells expressing the progenitor marker Sox2 and originating either from nerve terminals around hair follicles (HFs), from injured peripheral nerves or from distant sites outside the regenerating dermis...
Thus, in this study, we asked if, by approaching a specific status of glial cells, the inhibitory CNS environment can be reversed to support axon regeneration. Using a Drosophila CNS injury paradigm, we assessed CNS axon regeneration after manipulating various functional pathways in glial cells. ...
Neural crest cells (NCC) are multi-potent cells of ectodermal origin that colonize diverse organs, including the gastrointestinal tract to form the enteric nervous system (ENS) and hematopoietic organs (bone marrow, thymus) where they participate in lymp
In draper mutants, antennal lobe glia fail to expand membranes after antennal ablation, glia are not recruited to severed axons, and severed axons are not cleared from the CNS. Thus, in the absence of Draper, glial cells are unable to respond to axonal injury. In two companion manuscripts, ...
Dysfunction of glial cells, including astrocytes, oligodendrocytes, and microglia in the central nervous system (CNS), and Schwann cells or satellite cells in the peripheral nervous system (PNS) are strongly involved in damaging mechanisms depending on oxidative stress and inflammation [15,16,17,18,...
6,7.Drosophilaglial types are functionally similar to glia in mammals5. Ensheathing glia are the phagocytic cell type in the adult fly brain8while in the adult peripheral nervous system (PNS), wrapping and subperineurial glia were found to engulf most of the axon debris generated after injury...