transporter during intracellular transport in mammals, but not in Lysosomal 伪 -mannosidase uses GlcNAc-1-P transferase as a cargo salmon liverEilertsen, Karl ErikBerg, ThomasHeikinheimo, PirkkoMichalski, Jean ClaudeGreinertollersrud, Ole K
2.如权利要求1所述的化合物,或其药学上可接受的盐、溶剂合物、立体异构体或旋光 异构体,其特征在于,所述化合物为: 3.权利要求1或2所述的化合物,或其药学上可接受的盐、溶剂合物、立体异构体或旋光 异构体在制备O‑GlcNAc转移酶抑制剂中的用途。 4.如权利要求3所述的用途,其特征在于,所述O‑GlcNAc...
本发明公开了OGlcNAc糖苷酶抑制剂在制备治疗抑郁症药物中的应用.本发明OGlcNAc糖苷酶抑制剂在制备治疗代谢综合征诱发抑郁症药物中的应用.具体的,PUGNAc应用于制备治疗高脂饮食诱发肥胖共病抑郁症中.本发明对于治疗抑郁症具有见效快,疗效好﹑副作用小的优点,对于代谢综合征诱发抑郁症(尤其是高脂饮食诱发肥胖共病抑郁症...
Overall, our study provides valuable insights into the UDP-GlcNAc recognition mechanism by OGT, which could further aid in mechanistic studies of O-GlcNAc glycosylation and drug development targeting on OGT. 展开 关键词: O-GlcNAc transferase UDP-GlcNAc recognition Conformational dynamics Markov state ...