transporter during intracellular transport in mammals, but not in Lysosomal 伪 -mannosidase uses GlcNAc-1-P transferase as a cargo salmon liverEilertsen, Karl ErikBerg, ThomasHeikinheimo, PirkkoMichalski, Jean ClaudeGreinertollersrud, Ole K
Overall, our study provides valuable insights into the UDP-GlcNAc recognition mechanism by OGT, which could further aid in mechanistic studies of O-GlcNAc glycosylation and drug development targeting on OGT. 展开 关键词: O-GlcNAc transferase UDP-GlcNAc recognition Conformational dynamics Markov state ...
本发明化合对 OGT具有良好的亲和力和优异的抑制作用,能够 有效降低蛋白O‑GlcNAc修饰水平,降低c‑Myc蛋 白水平,抑制肝癌细胞增殖;在O‑GlcNAc异常糖 基化修饰导致的疾病,特别是肝癌的治疗药物中 有应用价值。 A 5 8 0 2 6 1 6 1 1 N C CN 116162085 A 权利要求书 1/1页 1.式I所示化合物,或其...