Heterogeneity of growth hormone (GH)-producing cells in aging male rats: in vitro GH releasing activity of somatotrope subpopula- tions. Mol Cell Endocrinol, 123: 127-137.Dobado-Berrios PM, Ruiz-Navarro A, Almaden Y, et al. 1996 Heterogeneity of growth hormone (GH)-producing cells in ...
A possible role of GH during central nervous system (CNS) development has been suggested by the presence of this hormone and its receptor in brain areas before its production by the pituitary gland. Although several effects have been reported for GH, the specific role of this hormone during CNS...
Growth Hormone exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway. 蛋白编号:P06880 (F27-F216) 基因ID:14599 产品分类:细胞因子和生长因子 | 肽激素和神经肽 | 生长激素 Categories:Cytokines and Growth Factors | Peptide Hormone & ...
Muscle cells, like almost all other cells in the body, show growth and metabolic responses to growth hormone (GH). Although GH actions are classically thought to be mediated via insulin-like growth factor I (IGF-I), it is now recognized that GH has direct actions via the GH receptor (...
The involvement of nitric oxide (NO) in human GH-releasing hormone (hGHRH)-induced GH secretion was studied with freshly dissociated male rat pituitary cells. The cells were packed in a column of Bio-Gel-P2 and continuously perifused at 37 C. Hemoglobin (Hb; 10 microM), which is known to...
However, GHRH administered in 1, 10 and 100 nM did not change progesterone and estradiol release from cultured granulosa cells. CONCLUSION: Growth hormone (GH) but not GHRH has direct stimulating effects on progesterone release from cultured rat granulosa cells. 展开 关键词: GH GH-RH estradiol ...
and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone(GHRH)and somatostatin(SST)as well as by signals from the periphery-ghrelin ...
HORMONE ACTION IN SKELETAL CELLS GH and IGF-I. The growth-promoting actions of GH and IGF-I have been reviewed recently (39). The original somato- medin hypothesis (40) proposed that GH stimulates hepatic production of IGF-I, which in turn promotes growth directly at the epiphyseal plate. ...
Growth hormone (GH)1acts on its target tissues by interacting with the transmembrane GH receptor (GHR) (1, 2). In multiple species, a substantial fraction of circulating GH is complexed with a high-affinity GH-binding protein (GHBP) that corresponds to the ligand-binding extracellular domain ...
JAK2, but not Src family kinases, is required for STAT, ERK, and AKT signaling in response to growth hormone in preadipocytes and hepatoma cells 2008, Molecular Endocrinology The Src signaling pathway: A potential target in melanoma and other malignancies 2007, Expert Opinion on Therapeutic Target...