Strangely, these cells were negative for the Purkinje cell marker calbindin in the cerebellum and the neuronal marker NeuN in the thalamus. Thus,contrary to previous studies, our genetic fate-mapping revealed that the cell fate of embryonic GFAP~+cells at the young adult stage is significantly ...
We show that GFAP + progenitor cells give rise to neurons and oligodendrocytes throughout the CNS. We find very little regional heterogeneity in the neurogenic potential of radial glia between dorsal and ventral telencephalon. Additionally, radial glia serve as precursors for subpopulations of ...
Mutation of PTEN-induced putative kinase 1 (PINK1) causes autosomal recessive early-onset Parkinson’s disease (PD). Despite of its ubiquitous expression in brain, its roles in non-neuronal cells such as neural stem cells (NSCs) and astrocytes were poorl
aat 7 and 14 days after focal strokes, these same peri-infarct areas lit up with increased MMP-9 signals that co-localized with NeuN-positive and GFAP- positive cells 在7和14天在焦点冲程以后,这些同样仙子梗塞区域容光焕发与增加的MMP-9发信号那co地方化与NeuN正面和GFAP-正面细胞 [translate] ...
Transfection studies showed that GFAP-delta suppresses GFAP filament formation, thereby possibly influencing the astrocytic cytoskelal and the migratory properties of these cells. Interestingly, a recent pilot showed an impressive expansion of the population of GFAP-delta+ cells in the SVZ in MS. ...
Recent studies indicate that in the adult, migrating SVZa-derived cells are ensheathed by astrocytes, although the function of these astrocytes has not been determined. To explore the possible role(s) of astrocytes in the rat SVZa and RMS, we examined the expression of astroglial-specific ...
Moreover, the scarcity of glial markers in the neonatal SVZa indicates that the forebrain subventricular zone includes a distinct neurogenic anterior region containing predominantly committed neuronal progenitor cells. 展开 关键词: development forebrain neurogenesis olfactory bulb progenitor cell ...
Although extensive research has been performed to control differentiation of neural stem cells – still, the response of those cells to diverse cell culture conditions often appears to be random and difficult to predict. To this end, we strived to obtain stabilized protocol of NHA cells differentiat...
With the formation of the external granular layer on E13, a few GFAP positive cells appear among the unstained external granular layer cells. First seen within the germinal trigone and caudalmost part of the external granular layer, they then develop rostrally, amongst the cells of the expanding...
Pathology Expression of the Gi-coupled RASSL Ro1 in GFAP-positive cells| A novel model of hydrocephalus THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Ken D. McCarthy SwegerElizabeth JoyHydrocephalus is a disorder of cerebrospinal fluid dynamics within the central nervous system. Although symptoms...