Genotype–phenotype mapping in a post-GWAS world. Trends Genet. 2012; 28 (9):421–426. doi: 10.1016/j.tig.2012.06.003. [ Cross Ref ]Nuzhdin SV, Friesen ML, McIntyre LM (2012) Genotype-phenotype mapping in a post-GWAS world. Trends in Genetics 28: 421-426....
摘要: The mapping between the genetic make-up and the phenotype of an organism is both complex and nonlinear, but the recognition that certain computer programs perform exactly such operations allows us to use the knowledge of the computer science domain to make progress in problems of genetics....
A multi-stage genotype-phenotype mapping is used to ensure feasible solutions and to decrease computational effort. The central idea behind this approach is to map the search-space to a so called solution space in a way that the size of the space is reduced and an additional constraint is in...
In view of this last mapping, we have defined 'phenotype' as the attributes of a biochemical system in steady-state determined by a unique set of values in the gene-by-environment space of model parameters. Elucidation of the mechanistic link from genotype and environment to phenotype is a ...
been available until recently. These estimates show that pleiotropy is highly restricted and are more in line with the notion of variational modularity than with universal pleiotropy. This finding has major implications for the evolvability of complex organisms and the mapping of disease-causing ...
Genotype-phenotype mapping plays an important role in the evolutionary process. In this paper, we argue that an adaptive mapping could help to solve a special class of highly epistatic problems known as rotated problems. Our conjecture is that co-evolving the mapping represented by a population ...
polymorphisms (SNPs) makes the haplotype-based method instead of single-maker-oriented method the main approach to association studies on QTL mapping. The... CK Wang,ZP Wang,XT Qiu,... - 《科学通报(英文版)》 被引量: 14发表: 2007年 A combined data mining approach for infrequent events: ...
These findings illustrate the power of genome-wide reverse genetics in genotype-phenotype mapping, uncover an enormous range of genetic complexity of phenotypic traits, and suggest that the GPM of cellular organisms has been shaped by natural selection for mutational robustness. © The Author ...
wecalcu-latedparameters orstaticanddynamicphenotypicstabilityo thedi erenttraitsandappliedlinkagemappingusingwhole-genomemolecularmarkerprofles.Whileweobservedanabsenceo large-e ectquantitativetraitloci(QTLs)underlyingyieldstability,largeandstableQTLswere ound orphenotypicstabilityo testweight,solublepentosancontent,and...
Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughput sequence data from the 75 base pairs long mutagen...