Genotype–phenotype mapping in a post-GWAS world. Trends Genet. 2012; 28 (9):421–426. doi: 10.1016/j.tig.2012.06.003. [ Cross Ref ]Nuzhdin SV, Friesen ML, McIntyre LM (2012) Genotype-phenotype mapping in a post-GWAS world. Trends in Genetics 28: 421-426....
摘要: The mapping between the genetic make-up and the phenotype of an organism is both complex and nonlinear, but the recognition that certain computer programs perform exactly such operations allows us to use the knowledge of the computer science domain to make progress in problems of genetics....
The pleiotropic structure of the genotype–phenotype map is strongly modular, meaning that sets of traits are co-controlled by sets of genes in a highly nonrandom manner. In contrast to current theoretical models of pleiotropy, empirical data show that the average phenotypic effect of a mutation ...
Genotype-phenotype mapping plays an important role in the evolutionary process. In this paper, we argue that an adaptive mapping could help to solve a special class of highly epistatic problems known as rotated problems. Our conjecture i... LT Bui,HA Abbass,D Essam - Recent Advances In Artif...
In view of this last mapping, we have defined 'phenotype' as the attributes of a biochemical system in steady-state determined by a unique set of values in the gene-by-environment space of model parameters. Elucidation of the mechanistic link from genotype and environment to phenotype is a ...
Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughput sequence data from the 75 base pairs long mutagen...
Microbial phenotypes are typically due to the concerted action of multiple gene functions, yet the presence of each gene may have only a weak correlation with the observed phenotype. Hence, it may be more appropriate to examine co-occurrence between sets of genes and a phenotype (multiple-to-on...
These findings illustrate the power of genome-wide reverse genetics in genotype-phenotype mapping, uncover an enormous range of genetic complexity of phenotypic traits, and suggest that the GPM of cellular organisms has been shaped by natural selection for mutational robustness. © The Author ...
810.76K 文档页数: 10页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 待分类 系统标签: phenotypicstabilityryegenotypeinsightsphenotype Journalo ExperimentalBotany,Vol.66,No.11pp.3275–3284,2015doi:10.1093/jxb/erv145AdvanceAccesspublication6April2015Thispaperisavailableonlinefreeofallacces...
www.nature.com/scientificreports OPEN Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity received: 19 November 2015 accepted: 08 April 2016 Published: 26 April 2016 and resistance in melanoma micrometastasis Guido Santos1,2,3, Svetoslav Nikolov1,4,5...