Here, phenotype-genotype mapping was used to dissect the betaine-triggered L-arginine overproduction mechanism and mine beneficial genes for further improving production phenotype. The comparative transcriptomic analysis revealed a novel role for betaine in modulating global gene transcription. Guided by ...
As we look forward to 2017, Cell Systems expects that advances in technology will redefine an age-old problem: the mapping of phenotype onto genotype. Several landmark papers published in recent weeks describe experimental methods to address this problem—Perturb-seq (Dixit et al., Cell 167, 18...
- git clone https://github.com/SakshiKhaiwal/Genotype-to-phenotype-mapping-in-yeast.git - cd Genotype-to-phenotype-mapping-in-yeast/pipeline - conda create -n GenPhen python=3.8 - conda activate GenPhen - pip install -r requirements.txt ...
Microbial phenotypes are typically due to the concerted action of multiple gene functions, yet the presence of each gene may have only a weak correlation with the observed phenotype. Hence, it may be more appropriate to examine co-occurrence between sets of genes and a phenotype (multiple-to-on...
Genome-scale engineering is an indispensable tool to understand genome functions due to our limited knowledge of cellular networks. Unfortunately, most existing methods for genome-wide genotype–phenotype mapping are limited to a single mode of genomic alteration, i.e. overexpression, repression, or de...
From genotype to phenotype unraveling the complexities of… 热度: dbVOR a database system for importing pedigree phenotype and genotype data and exporting 热度: genotype-phenotype correlations in von hippel-lindau disease 热度: Journalo ExperimentalBotany,Vol.66,No.11pp.3275–3284,2015 ...
Genome-scale engineering is an indispensable tool to understand genome functions due to our limited knowledge of cellular networks. Unfortunately, most existing methods for genome-wide genotype–phenotype mapping are limited to a single mode of genomic alteration, i.e. overexpression, repression, or de...
In view of this last mapping, we have defined 'phenotype' as the attributes of a biochemical system in steady-state determined by a unique set of values in the gene-by-environment space of model parameters. Elucidation of the mechanistic link from genotype and environment to phenotype is a ...
Genome Biology (2023) 24:196 https://doi.org/10.1186/s13059-023-03044-2 Genome Biology RESEARCH Open Access A high‑resolution genotype–phenotype map identifies the TaSPL17 controlling grain number and size in wheat Yangyang Liu1,2†, Jun Chen3†, Changbin Yin4†, Zi...
The pleiotropic structure of the genotype–phenotype map is strongly modular, meaning that sets of traits are co-controlled by sets of genes in a highly nonrandom manner. In contrast to current theoretical models of pleiotropy, empirical data show that the average phenotypic effect of a mutation ...