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Here, we perform life history analysis on an indigenous Black African population, underscoring the critical paucity of genomic data previously available from breast cancer patients of African ancestry15,16. Results High-depth WGS was performed on 100 breast tumors (90 × depth; of which 49 ha...
Lane DP (1992) Cancer. p53, guardian of the genome. Nature 358(6381):15–16 CAS PubMed Google Scholar Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F et al (2018) Comparative molecular analysis of gastrointestinal adenocarcinomas. Cell 33(4):721–735 CAS Google...
“the guardian of the genome,” and it controls cell fate after DNA damage such asDNA repairand survival or programmed death. Not surprisingly, TP53 is one of the most frequently mutated genes (>50%) in human cancer[114]. As TP53 is a DNA damage–checkpoint protein, its inactivation was...
This study was approved by the Institutional Review Board and Protocol Review Committee of the Korean Cancer Study Group (protocol number AL22-09) and by the review boards of all 31 institutions. Informed consent will be obtained from all patients and/or their legal guardian(s) in compliance ...
variants in the fetus that predispose adults to develop breast cancer when a majority will either never develop tumors or develop them at a life stage where treatment is not beneficial. Prenatal detection could mean that parents might elect to terminate their pregnancy based on a dubious cancer ...
S4B). We went on to test if the positive correlation between BRCA1 and 53BP1 expression levels in breast cancer samples are influenced by prognostic molecular profiling factors. We first separated breast cancer samples into two groups based on estrogen receptor (ER) expression status (positive or...
genome (hg19/GRCh37) using BioScope 1.2 (Life Technologies). The percentage of mapped reads was 69.2 % (SD = 6.2). We deleted reads with multiple poor quality alignments and high copy number duplicate reads were collapsed to single reads. This led to the elimination of 32.1 % of the...
ultimately generating mutations and chromosomal aberrations that could contribute significantly to tumorigenesis. Upon DNA damage a series of guardian events occur, including the cellular recognition of DNA damage lesion site, initiation and amplification of DNA damage signal to activate DNA damage checkpoint...
One of the main effects of radiation exposure is the formation of single strand (ssDNA) and DNA double-strand breaks (DSB) together referred to as DNA damage56. High DSB levels can lead to cell death and low levels of DSB result in genomic rearrangements and may lead to cancer. In this...