Genomic therapy for the treatment of Cancer: A reviewGokhale, NiharikaJain, SanjaySingh, R. P.International Journal of Pharmacy & Life Sciences
et al. Cancer genome interpreter annotates the biological and clinical relevance of tumor alterations. Genome Med. 10, 25 (2018). Article PubMed PubMed Central CAS Google Scholar Dumbrava, E. I. & Meric-Bernstam, F. Personalized cancer therapy-leveraging a knowledge base for clinical ...
In this Review, we discuss the impact of co-mutations on the pathogenesis, biology, microenvironmental interactions and therapeutic vulnerabilities of non-small-cell lung cancer and assess the challenges and opportunities that co-mutations present for personalized anticancer therapy, as well as the ...
Anaplastic thyroid cancer (ATC) is one of the most aggressive and lethal types of cancer and treatment options remain very limited. The majority of patients present initially with metastatic disease and require systemic therapy. The shift from conventional cytotoxic therapies to more specific, molecular...
The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mu
Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality and continues to increase. Current standard of care for patients wit... D Liu,KF Staveley-O - 《Journal of Clinical & Cellular Immunology》 被引量...
Genetic insight and therapeutic targets in squamous-cell lung cancer Here, we provide a review on these discoveries and their implications for clinical trials in squamous-cell lung cancer assessing the value of novel ... ML Sos,RK Thomas - 《Oncogene》 被引量: 123发表: 0年 ...
Finally, there is emerging interest in using molecular data to guide cancer prevention, through efforts such as the Pre-Cancer Atlas (Spira et al., 2017). The observation of increased DNA methylation in a significant proportion of IMs raises the potential for low-dose epigenetic therapy as a ...
2021 in Review Nature Cancer (Nat Cancer)ISSN2662-1347(online) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research, free to your inbox weekly. Email address Sign up I agree my information will be processed in accordance with theNatureand Springer Nature LimitedPri...
Muscle-invasive bladder cancer (MIBC) is an aggressive disease with limited therapeutic options. Although immunotherapies are approved for MIBC, the majority of patients fail to respond, suggesting existence of complementary immune evasion mechanisms. He