--fast Faster analysis (default='0') * 'trimmomatic' is used for read quality filtering * 'megahit' is used as assembler * contig ordering and pangenome analysis are disabled * only gene prediction but not annotation is performed --filtering Select the software for filtering the reads. Optio...
近日,中国农业科学院深圳农业基因组研究所(岭南现代农业科学与技术广东省实验室深圳分中心)刘毓文课题组联合佛山鲲鹏现代农业研究院唐中林课题组在自然指数期刊《基因组研究(Genome Research)》杂志上在线发表了题为“Analyzing super-enhancer temporal...
Molecular tools enabling precise DNA mutations and targeted modulation of gene expression have significant potential in medicine and biology. Here, the authors develop a compact system for simultaneous and independent gene editing, activation, and repression in mammalian cells. Qichen Yuan Hongzhi Zeng Xu...
近日,中国农业科学院深圳农业基因组研究所(岭南现代农业科学与技术广东省实验室深圳分中心)刘毓文课题组 联合佛山鲲鹏现代农业研究院唐中林课题组在自然指数期刊《基因组研究(Genome Research)》杂志上在线发表了题为“Analyzing super-enhancer temporal dynamics reveals potential critical enhancers and their gene regulatory...
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse
现代作物“Gene pool”的遗传变异涉及到SNPs,InDels及SVs,这些变异信息为作物的人为选择及自然选择提供原始的材料,了解变异产生的过程,探究不同材料的变异程度并利用有利的变异对维持并提高作物生产力至关重要,用以满足气候环境变化下日益增长的世界人口的迫切的需求。
备注【A : 物种远 一般用gene 蛋白 比对(blastp diamondg再用mcscan 找共线性块) B : 物种近 ,直接用genome数据分析,(一般是同一个种 不同品种的基因组用 minimap2 mummer找共线性区域 ) 两个物种太远了,用这个程序从DNA没有找到共线性块,那么建议先用蛋白找到共线性块】 ...
MAGPIE prediction on gene mutations that cause Mendelian diseases Next, we applied MAGPIE to four genes curated with a large number of known pathogenic mutations causing different Mendelian diseases (Methods). For all the four genes tested, i.e., ATP7B, CFTR, FBN1, and LMNA, MAGPIE was able...
33 gene fusions were previously reported for PCa, including two of the top six recurrent gene fusions ZBTB20-LSAMP (4 tumours of which three are African-derived), and the well-established PCa fusion gene TMPRSS2-ERG (31 tumours) [34]. Among the novel gene fusions identified, 144 are ...
DNA-free genome editing technology in plants is new and began in 2015, and since then great advances have been made on producing transgenic-free genome-edited plants. The exogenous CRISPR/Cas cassette and other transgenes could be eliminated by multiple approaches after the target gene has been ...