但人类并不是基因组大小（genome size）最大的生物。基因组大小并不直接与生物的复杂性成正比，这个现象...
Although the human bladder is reported to harbor unique microbiota, our understanding of how these microbial communities interact with their human hosts is limited, mostly owing to the lack of isolates to test mechanistic hypotheses. Niche-specific bacterial collections and associated reference genome dat...
Besides, we introduced diverse biological functions of repeats and reviewed existing methods for automatic repeat detection, classification, and masking. Finally, we analyzed the type, structure, and regulation of repeats in the human genome and their role in the induction of complex diseases. We ...
Strong purifying selection is considered a major evolutionary force behind small microbial genomes in the resource-poor photic ocean. However, very little is currently known about how the size of prokaryotic genomes evolves in the global ocean and whethe
Our bioinformatics study estimates the size of 'druggable' human genome to be around 20% of human proteome, i.e. the number of the possible protein targets for small-molecule drug design in medicinal chemistry. We do not take into account any toxicity prediction, the three-dimensional ...
Previously, scientists supposed that the risk of developing cancer should increase with both the number of cells (large bodies) and an organism's lifespan. The white shark has a huge size of genome, one-and-a-half times the size the the human genome. ...
It suggested that the tree shrew's genomic structure had a higher similarity to that of primates than to mice, said the researchers. The researchers said that they hope the database will provide more help for studying tree shrew biology and modeling human diseases with tree shew models....
numbers and positions of segregating sites were generated from all the somatic chromosomes. The results were plotted using R (Team2018). We adjusted the outcome by setting a mutation rate of 0.5 × 10−9bp−1year−1as suggested by the work on human evolution by Scally (Scally2016...
NOTE1:Optional argument--refshould match the name of the folder indata_repowhich corresponds to the version of human reference genome used in the BAM file. NOTE2:The user should be aware that AA uses intermediate files with prefix provided to--out. If these files are already present then ...
whereas Bxb1 requires pre-installation of its preferred attachment site in the human genome18. A major advantage of LSRs over other emerging technologies is that there is no obvious upper limit on the size of the donor DNA, with reports demonstrating successful 27-kb integration into mammalian ...