tiger evolution whole-genome sequencing adaptation Results and Discussion Genome-wide Evidence for Six Living Tiger Subspecies Current tiger taxonomy, informed by molecular genetic evidence, recognizes six living subspecies [3, 4, 5, 9, 10], including the Bengal tiger Panthera tigris tigris (Linnaeus...
Notably, CRISPR/Cas9, coupled with next-generation sequencing (NGS), is applied in the personalized treatment of cancer [46,47]. This involves using CRISPR/Cas9 to disable or repair genes implicated in cancer development, while NGS identifies patient-specific genetic mutations [8]. The acquired ...
A shadow of uncertainty due to patent infringement liability hovers over whole-genome/exome sequencing tests, but initial empirical work suggests that there may be greater freedom to operate than perceived [13, 14]. Despite the equivocal nature of the evidence, controversy persists, as highlighted ...
There is an increasing move towards the use of multi-gene panels, whole-genome sequencing (WGS) and whole-exome sequencing (WES) in clinical care. In contrast to genetic testing for mutations in a single gene or in a limited number of high-penetrance genes associated with a particular diseas...
[1,2]. Analytical and social-justice considerations both recommend thoughtful assessment of the role of social identity, particularly racial or ethnic identity, in the design, conduct and dissemination of clinical and basic science research. Controversies ranging from James Watson's comments on racial...
Summary of Principles Agreed at the International Strategy Meeting on Human Genome Sequencing. 1996, Bermuda, [http://www.ornl.gov/sci/techresources/Human_Genome/research/bermuda.shtml#1] Fort Lauderdale Agreement. Sharing Data from Large-scale Biological Research Projects: A System of Tripartite ...