By using targeted genome editing, we obtained an allele of RBL1, named RBL1~(螖12), which confers broad-spectrum disease resistance but does not decrease yield in a model rice variety, as assessed in small-scale field trials. Our study has demonstrated the benefits of editing an LMM gene,...
Genome editing of a rice CDP-DAG synthase confers multipathogen resistance Article 14 June 2023 Mutations introduced in susceptibility genes through CRISPR/Cas9 genome editing confer increased late blight resistance in potatoes Article Open access 24 February 2021 An Aegilops longissima NLR protein ...
The discovery and application of genome editing introduced a new era of plant breeding by giving researchers efficient tools for the precise engineering of crop genomes. Here we demonstrate the power of genome editing for engineering broad-spectrum disease resistance in rice (). We first isolated a...
(Nature, doi:10.1038/s41586-023-06205-2, 2023), focusing on the cloning of theRBL1gene from rice, which is associated with lesion mimic mutant (LMM) traits. TheRBL1gene encodes a cytidine diphosphate diacylglycerol (CDP-DAG) synthase and plays a crucial role in regulating cell death and ...
One of the therapeutic approaches tried for OPA1-related mitochondrial diseases is genome editing using small ribonucleoprotein particle U1 (U1 snRNP), especially since 30% of OPA1 pathogenic variants are splice-site [99]. Jüschke et al. showed that engineered U1 splice factors targeted to intron...
plants Article Genome-Wide Identification of WRKY Genes in Artemisia annua: Characterization of a Putative Ortholog of AtWRKY40 Angelo De Paolis 1,* , Sofia Caretto 1,* , Angela Quarta 1, Gian-Pietro Di Sansebastiano 2 , Irene Sbrocca 3, Giovanni Mita 1,† and Giovanna Frugis 3,† 1...