Cardiovascular disease (CVD) is a leading health problem, affecting more than 80,000,000 individuals in the United States alone. CVD encompasses a broad range of disorders, including diseases of the vasculature,
2012. Genetics of human cardiovascular disease. CellKathiresan, S. & Srivastava, D. Genetics of Human Cardiovascular Disease. Cell 148, 1242- 1257 (2012).Kathiresan S, Srivastava D: Genetics of human cardiovascular disease. Cell 2012, 148:1242-1257....
Clonal haematopoiesis of indeterminate potential (CHIP) is defined as an expansion of mutant blood stem cells in individuals without haematological malignancies. CHIP is linked to an increased risk of non-cancerous disorders such as atherosclerotic cardiovascular disease, possibly because mutant innate immu...
A primary goal of human genetics is to identify DNA sequence variants that influence biomedical traits, particularly those related to the onset and progression of human disease. Over the past 25 years, progress in realizing this objective has been transformed by advances in technology, foundational ...
However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will ...
associations between neuroticism and MDD, includingRBFOX1, RERE, SOX5,andTCF4, and those contributing to the causal associations between neuroticism and cardiovascular diseases, includingMAD1L1,ARNTL,RERE, andSOX6. The present study indicates that genetic variation mediates the causal influences of ...
Cardiovascular disease genetics: a long and winding roadOrdovas, Jose M.Abstract Purpose of review: This review has two major goals. The first goal is to raise some of the methodological problems associated with studying the genetics of complex disorders, specifically cardiovascular diseases. The ...
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Genetic predisposition to disease References Abdel-Salam E, Abdel Khalik A, Abdel-Meguid A, Barakat W, Mahmoud AA (1986) Association of HLA class I antigens (A1, B5, B8 and CW2) with disease manifestations and infection in human schistosomiasis mansoni in Egypt. Tissue Antigens 27:142–146...
This study found that genetic predisposition to longer telomeres increased risk of multiple cancers but reduced risk for some other diseases, including cardiovascular disease. Article Google Scholar Codd, V. et al. Identification of seven loci affecting mean telomere length and their association with ...