Unlike other lung diseases that have a significant heritable genetic component (e.g., cystic fibrosis), lung cancer is primarily caused by somatic mutations induced by environmental toxins such as cigarette smoke. Somatic mutations that occur in key cellular pathways drive lung carcinogenesis by ...
近日，同济大学附属上海市肺科医院张鹏团队联合同济大学生科院王晨飞团队，同济大学医学院孙毅团队与中科院生化细胞所曾安团队，于Nature Genetics 杂志在线发表题为Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small cell lung cancer的研究论文。该研究利用空间转录组...
2、Hogan, B. L. et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell 15, 123–138 (2014). 3、Kim, C. F. et al. Identifcation of bronchioalveolar stem cells in normal lung and lung cancer. Cell ...
使用模块基因的整体表达表示癌细胞状态,同时利用空间转录组技术探究了癌细胞状态与肿瘤微环境中特定细胞类型分布的关系,这为理解不同状态的癌细胞如何与肿瘤微环境相互作用,以形成免疫逃逸,并发生耐药、转移和复发的机制奠定了重要基础。
lung-cancer-molecular-drivers.jpg Chromosome aberrations Chromosomal instability, aneuploidy, and loss of heterozygosity; There are several types of genetic damage that contribute to lung cancer pathogenesis: (i) changes in chromosome number; ...
There exists sufficient evidence supporting a genetic component to lung cancer development. However, the genes involved and the exact mechanisms underlying individual susceptibility to lung cancer development are still unclear. Advances in cellular biology and laboratory methods are rapidly evolving and will...
(3) radiologic detection of spinal osteoporosis (at age 15, chances of such osteoporosis having been detected: 36% and 64%, respectively); and (4) ... SH Mudd,F Skovby,HL Levy,... - 《American Journal of Human Genetics》 被引量: 3488发表: 1985年 World Health Organization classification...
In this biomarker cohort analysis of CheckMate 153, analyses of genomic alterations and neoepitope immunogenicity in tumor tissue samples from patients with non-small cell lung cancer treated with nivolumab show the evolution of neoantigens during nivolumab-induced selection pressure and how it associates...
Epidermal growth factor receptor (EGFR)-targeted therapies have demonstrated remarkable success in a small subset of non-small cell lung cancer patients. The mechanism of response has been an area of active research, with somatic mutation in a number of genes in the EGFR signal transduction pathway...
The molecular mechanisms underlying stage I non-small cell lung cancer (NSCLC) remain poorly understood. Here, the authors do multi-omics profiling of paired tumor and normal adjacent tissues from NSCLC patients, finding molecular processes and cell type proportions that are associated with recurrence...